The regulation and function of phosphate in the human body
The regulation and function of phosphate in the human body
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DOI：
10.1002/biof.552210167
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发表时间：
2004
期刊：
影响因子：
6
通讯作者：
E. Takeda;Y. Taketani;N. Sawada;Tadatoshi Sato;Hironori Yamamoto
中科院分区：
文献类型：
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作者：
E. Takeda;Y. Taketani;N. Sawada;Tadatoshi Sato;Hironori Yamamoto
无机磷酸盐（Pi）是细胞功能和骨骼矿化所必需的。血清Pi水平通过肠道吸收、与细胞内和骨储存池交换以及肾小管重吸收之间的复杂相互作用维持在一个狭窄的范围内。日粮中含有丰富的π，其肠道吸收效率高，且受调控最小。肾脏是Pi稳态的主要调节者，可以增加或减少其Pi再吸收能力以适应Pi的需要。Pi稳态的关键调控步骤是Pi通过肾近端小管的运输。II型钠依赖性磷酸钠（Na/Pi）共转运蛋白（NPT2）是肾近端小管中的主要分子，受激素和非激素因素的调节。
Inorganic phosphate (Pi) is required for cellular function and skeletal mineralization. Serum Pi level is maintained within a narrow range through a complex interplay between intestinal absorption, exchange with intracellular and bone storage pools, and renal tubular reabsorption. Pi is abundant in the diet, and intestinal absorption of Pi is efficient and minimally regulated. The kidney is a major regulator of Pi homeostasis and can increase or decrease its Pi reabsorptive capacity to accommodate Pi need. The crucial regulated step in Pi homeostasis is the transport of Pi across the renal proximal tubule. Type II sodium‐dependent phosphate (Na/Pi) cotransporter (NPT2) is the major molecule in the renal proximal tubule and is regulated by hormones and nonhormonal factors.