A specific role for serotonin in overcoming effort cost
A specific role for serotonin in overcoming effort cost
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DOI：
10.7554/elife.17282
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发表时间：
2016-11-08
期刊：
影响因子：
7.7
通讯作者：
Gaillard, Raphaeel
中科院分区：
文献类型：
--
作者：
Meyniel, Florent;Goodwin, Guy M.;Gaillard, Raphaeel
血清素与行为调节的许多方面有关。理论尝试统一分配给血清素的多种角色，提出它调节成本的影响，如延迟或惩罚，对行动选择。在这里，我们表明血清素也调节其他类型的行动成本，如努力。我们比较了58名健康人在8周内服用安慰剂或选择性5 -羟色胺再摄取抑制剂艾司西酞普兰的行为表现。这项任务涉及到用握力生产换取金钱利益。艾司西酞普兰组的参与者付出了更多的努力，从而获得了更高的回报。至关重要的是，我们的计算分析表明，这种效应是由努力成本的特定减少所支撑的，而不是由货币激励权重的任何变化所支撑的。这种特殊的计算效应揭示了血清素在行为调节中的生理作用和抑郁症药物的临床效果。
Serotonin is implicated in many aspects of behavioral regulation. Theoretical attempts to unify the multiple roles assigned to serotonin proposed that it regulates the impact of costs, such as delay or punishment, on action selection. Here, we show that serotonin also regulates other types of action costs such as effort. We compared behavioral performance in 58 healthy humans treated during 8 weeks with either placebo or the selective serotonin reuptake inhibitor escitalopram. The task involved trading handgrip force production against monetary benefits. Participants in the escitalopram group produced more effort and thereby achieved a higher payoff. Crucially, our computational analysis showed that this effect was underpinned by a specific reduction of effort cost, and not by any change in the weight of monetary incentives. This specific computational effect sheds new light on the physiological role of serotonin in behavioral regulation and on the clinical effect of drugs for depression.