Memory consolidation of fear conditioning: Bi-stable amygdala connectivity with dorsal anterior cingulate and medial prefrontal cortex
Memory consolidation of fear conditioning: Bi-stable amygdala connectivity with dorsal anterior cingulate and medial prefrontal cortex
复制标题
恐惧调节的记忆巩固：双稳态杏仁核与背侧前扣带皮层和内侧前额叶皮层的连接
DOI：
10.1093/scan/nst170
复制
发表时间：
2014-11-01
影响因子：
4.2
通讯作者：
Lei, Xu
中科院分区：
文献类型：
--
作者：
Feng, Pan;Feng, Tingyong;Lei, Xu
对啮齿动物和人类恐惧条件化的研究已经阐明了恐惧获得和消退的神经机制。然而，恐惧条件反射记忆巩固的神经机制还不是很清楚。为了解决这个问题，我们使用静息态功能磁共振成像测量了恐惧获得后的大脑活动和功能连接的变化。在恐惧记忆巩固过程中，杏仁核-背侧前扣带皮层（dACC）和背侧前扣带皮层（mPFC）的功能连接增强，而杏仁核-内侧前额叶皮层（mPFC）的功能耦合减弱。此外，杏仁核-mPFC功能连接与主观恐惧等级呈负相关。这些结果表明杏仁核与dACC和mPFC的功能连接可能在恐惧条件化的记忆巩固中起重要作用。杏仁核-mPFC功能连接的改变可以预测主观恐惧。因此，本研究为理解恐惧记忆巩固提供了一个新的视角。
Investigations of fear conditioning in rodents and humans have illuminated the neural mechanisms of fear acquisition and extinction. However, the neural mechanism of memory consolidation of fear conditioning is not well understood. To address this question, we measured brain activity and the changes in functional connectivity following fear acquisition using resting-state functional magnetic resonance imaging. The amygdala-dorsal anterior cingulate cortex (dACC) and hippocampus-insula functional connectivity were enhanced, whereas the amygdala-medial prefrontal cortex (mPFC) functional coupling was decreased during fear memory consolidation. Furthermore, the amygdala-mPFC functional connectivity was negatively correlated with the subjective fear ratings. These findings suggest the amygdala functional connectivity with dACC and mPFC may play an important role in memory consolidation of fear conditioning. The change of amygdala-mPFC functional connectivity could predict the subjective fear. Accordingly, this study provides a new perspective for understanding fear memory consolidation.