The role of clock genes and circadian rhythm in the development of cardiovascular diseases
The role of clock genes and circadian rhythm in the development of cardiovascular diseases
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DOI：
10.1007/s00018-015-1923-1
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发表时间：
2015-05
影响因子：
8
通讯作者：
Norihiko Takeda;K. Maemura
中科院分区：
文献类型：
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作者：
Norihiko Takeda;K. Maemura
心血管疾病如心肌梗死或室性心律失常的发病时间具有昼夜节律。自主神经活动、血浆皮质醇水平或肾素-血管紧张素活性的日变化是心血管疾病发病机制的基础。时钟基因的转录-翻译反馈回路构成了分子时钟系统。除了视交叉上核的中央时钟外，时钟基因也以昼夜节律的方式在每个器官中表达，以构成外周时钟。外周时钟似乎有利于预期外部刺激，从而有助于维持器官稳态。中枢和外周时钟之间的同步丧失也会增加疾病的进展。此外，越来越多的证据表明，时钟基因影响炎症和细胞内代谢信号。通过识别时钟控制基因来阐明分子钟在心血管病理中的作用将有助于建立一种新的心血管疾病治疗方法。
The time of onset of cardiovascular disorders such as myocardial infarctions or ventricular arrhythmias exhibits a circadian rhythm. Diurnal variations in autonomic nervous activity, plasma cortisol level or renin–angiotensin activity underlie the pathogenesis of cardiovascular diseases. Transcriptional–translational feedback loop of the clock genes constitute a molecular clock system. In addition to the central clock in the suprachiasmatic nucleus, clock genes are also expressed in a circadian fashion in each organ to make up the peripheral clock. The peripheral clock seems to be beneficial for anticipating external stimuli and thus contributes to the maintenance of organ homeostasis. Loss of synchronization between the central and peripheral clocks also augments disease progression. Moreover, accumulating evidence shows that clock genes affect inflammatory and intracellular metabolic signaling. Elucidating the roles of the molecular clock in cardiovascular pathology through the identification of clock controlled genes will help to establish a novel therapeutic approach for cardiovascular disorders.