Preliminary Evidence of an Association Between an Interleukin 6 Promoter Polymorphism and Self-Reported Attentional Function in Oncology Patients and Their Family Caregivers
Preliminary Evidence of an Association Between an Interleukin 6 Promoter Polymorphism and Self-Reported Attentional Function in Oncology Patients and Their Family Caregivers
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DOI：
10.1177/1099800413479441
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发表时间：
2014-04-01
影响因子：
2.5
通讯作者：
Miaskowski, Christine
中科院分区：
文献类型：
--
作者：
Merriman, John D.;Aouizerat, Bradley E.;Miaskowski, Christine
亚组的个人可能会在更大的风险，尼古丁引起的注意力功能的变化。本研究的目的是识别具有不同注意力功能轨迹的个体亚组，并评估表型和基因型（即，细胞因子基因多态性）的差异。在放射治疗前和6个月内的6次额外评估中，使用注意力功能指数对252名参与者（167名肿瘤患者和85名家庭护理人员）的自我报告注意力功能进行了评估。使用增长混合模型确定了三种潜在的注意功能：中度（36.5%），中度到高度（48.0%）和高度（15.5%）注意功能。中度班的参与者明显比其他两个班的参与者年轻，有更多的合并症和较低的功能状态。然而，只有功能状态在多变量模型中仍然显着。包括在15个候选基因中的92个单核苷酸多态性（SNPs）的遗传关联分析。对每个SNP评估加性、显性和隐性遗传模型。控制功能状态，只有白细胞介素6（IL 6）rs 1800795仍然是一个显着的基因型预测类成员在多变量模型。每增加一个罕见的“G”等位基因拷贝，属于低注意力功能类别的几率就会增加4倍（95%置信区间：[1.78，8.92]; p = .001）。研究结果提供了初步的证据，亚组的个人与不同的轨迹的注意力功能和遗传关联与IL 6启动子多态性。
Subgroups of individuals may be at greater risk of cytokine-induced changes in attentional function. The purposes of this study were to identify subgroups of individuals with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) differences among these subgroups. Self-reported attentional function was evaluated in 252 participants (167 oncology patients and 85 family caregivers) using the Attentional Function Index before radiation therapy and at six additional assessments over 6 months. Three latent classes of attentional function were identified using growth mixture modeling: moderate (36.5%), moderate-to-high (48.0%), and high (15.5%) attentional function. Participants in the moderate class were significantly younger, with more comorbidities and lower functional status, than those in the other two classes. However, only functional status remained significant in multivariable models. Included in the genetic association analyses were 92 single nucleotide polymorphisms (SNPs) among 15 candidate genes. Additive, dominant, and recessive genetic models were assessed for each SNP. Controlling for functional status, only Interleukin 6 (IL6) rs1800795 remained a significant genotypic predictor of class membership in multivariable models. Each additional copy of the rare "G" allele was associated with a 4-fold increase in the odds of belonging to the lower attentional function class (95% confidence interval: [1.78, 8.92]; p = .001). Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism.