SICKNESS BEHAVIOR AS A NEW TARGET FOR DRUG DEVELOPMENT
SICKNESS BEHAVIOR AS A NEW TARGET FOR DRUG DEVELOPMENT
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DOI：
10.1016/0165-6147(92)90012-u
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发表时间：
1992-01-01
影响因子：
13.8
通讯作者：
DANTZER, R
中科院分区：
文献类型：
--
作者：
KENT, S;BLUTHE, RM;DANTZER, R
疾病行为是指伴随对感染的反应而出现的非特异性症状（厌食、抑郁活动、对日常活动失去兴趣、身体护理活动消失）。越来越多的证据表明，这些症状是对抗原攻击的有组织防御反应的一部分，它们是由白细胞介素1等细胞因子的神经作用介导的。了解与这些影响有关的机制，将有助于开发旨在减少疾病或促进康复过程的新药。
Sickness behavior refers to the nonspecific symptoms (anorexia, depressed activity, loss of interest in usual activities, disappearance of body-care activities) that accompany the response to infection. Increasing evidence suggests that these symptoms are part of an organized defense response to antigenic challenge and that they are mediated by the neural effects of cytokines such as interleukin 1. An understanding of the mechanisms involved in these effects should permit development of new drugs aimed at decreasing sickness or promoting recovery processes.