The origins of polypoidal choroidal vasculopathy
The origins of polypoidal choroidal vasculopathy
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DOI：
10.1136/bjo.2004.049296
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发表时间：
2005-05-01
影响因子：
4.1
通讯作者：
Kawamura, A
中科院分区：
文献类型：
--
作者：
Yuzawa, M;Mori, R;Kawamura, A
背景/目的：关于息肉状脉络膜血管病变（PCV）的发病机制有两种理论：脉络膜新生血管（CNV）变异和脉络膜内血管异常。在使用摄像系统的吲哚菁绿色血管造影（伊加）中，PCV具有特征性外观，但图像质量不足导致难以进行详细解释。本研究的目的是提高成像，共聚焦扫描激光检眼镜（SLO），以阐明PCV的发病机制。方法：45眼（44例）的高速伊加与共聚焦SLO显示了典型的PCV的表现，分支血管网络和息肉样lesions.Results：血管组成的分支网络开始同时充满周围脉络膜动脉在38只眼睛。在伊加的动脉期和动静脉期，少量血管填充在分支网络内，表现出局灶性扩张、收缩和迂曲。血管异常，对应于息肉样病变，存在于一个网络中的8只眼睛，包括循环类似的口径网络血管，和众多的小血管的微血管瘤样扩张。结论：PCV是由脉络膜内血管异常引起的，而非CNV。
Background/aim: There are two theories on the pathogenesis of polypoidal choroidal vasculopathy (PCV): variants in choroidal neovascularisation (CNV) and inner choroidal vessel abnormalities. On indocyanine green angiography (IGA) with a video camera system, PCV has a characteristic appearance, but inadequate image quality has made detailed interpretation difficult. This study aims to improve imaging, using confocal scanning laser ophthalmoscopy (SLO), to elucidate the pathogenesis of PCV.Methods: High speed IGA with confocal SLO of 45 eyes (44 patients) showed typical PCV findings of a branching vascular network and polypoidal lesions.Results: Vessels comprising branching networks began to fill simultaneously with the surrounding choroidal arteries in 38 eyes. Small numbers of vessels filling within a branching network, in the arterial and arteriovenous phases of IGA, showed focal dilatation, constriction, and tortuousity. Vessel abnormalities, corresponding to polypoidal lesions, existed within a network in eight eyes and included loops similar in calibre to network vessels, and numerous microaneurysmal dilatations of small vessels. Vessel pulsation was seen in 24 eyes.Conclusion: PCV is caused by inner choroidal vessel abnormalities, not CNV.