Ink Formulation and Selection for Biological Applications of Two-Photon Polymerization
Ink Formulation and Selection for Biological Applications of Two-Photon Polymerization
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DOI：
10.1021/acsaom.3c00165
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发表时间：
2023-08
期刊：
影响因子：
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通讯作者：
S. M. Panda;H. Hosseinabadi;Hoda Fattel;Umakanta Tripathy;A. Miri
中科院分区：
文献类型：
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作者：
S. M. Panda;H. Hosseinabadi;Hoda Fattel;Umakanta Tripathy;A. Miri
双光子聚合（TPP）利用光交叉聚合前体中的非线性光相互作用来产生高分辨率（~ 100 nm）结构和高维度保真度。在TPP中使用近红外光源导致更少的散射和更高的穿透深度，使其在创建生物模型和组织支架方面具有吸引力。由于无与伦比的灵活性和空间分辨率，它们的范围从微血管结构到微针和支架。本文综述了TPP印刷结构的工作原理和当前使用的油墨。我们讨论了TPP在组织工程、血管化模型和其他生物医学应用中优于传统增材制造方法的优势。这篇评论提供了一个简短的配方，为所需的结构选择油墨和光引发剂。
Two-photon polymerization (TPP) uses nonlinear light interactions in photo-cross-linkable precursors to create high-resolution (∼100 nm) structures and high dimensional fidelity. Using a near-infrared light source in TPP results in less scattering and a higher penetration depth, making it attractive for creating biological models and tissue scaffolds. Due to unmatched flexibility and spatial resolution, they range from microvascular constructs to microneedles and stents. This review reviews the working principles and current inks used for TPP-printed constructs. We discuss the advantages of TPP over conventional additive manufacturing methods for tissue engineering, vascularized models, and other biomedical applications. This review provides a short recipe for selecting inks and photoinitiators for a desired structure.