Chromium(II)-Catalyzed Amination of N-Heterocyclic Chlorides with Magnesium Amides
Chromium(II)-Catalyzed Amination of N-Heterocyclic Chlorides with Magnesium Amides
复制标题
DOI：
10.1055/s-0034-1380178
复制
发表时间：
2015-02
期刊：
影响因子：
2
通讯作者：
A. Steib;Sarah Fernandez;O. Kuzmina;Martin Corpet;C. Gosmini;P. Knochel
中科院分区：
文献类型：
--
作者：
A. Steib;Sarah Fernandez;O. Kuzmina;Martin Corpet;C. Gosmini;P. Knochel
摘要我们报道了一种无配体铬(II)催化的N-杂环氯化物的胺化反应。在氯化锂存在下，CrCl2选择性地催化氯代吡啶和二氯吡啶、二氯喹啉、二氯异喹啉和二氯喹恶啉与一系列脂肪族、烯丙基、苄基和饱和(杂环)环状镁酰胺的反应。反应在50℃的四氢呋喃中进行，得到了所需的胺化产物，产率为56%-96%。
Abstract We report a ligand-free chromium(II)-catalyzed amination reaction of various N-heterocyclic chlorides. CrCl2 regioselectively catalyzes the reaction of chloropyridines and dichloropyridines, dichloroquinolines, dichloroisoquinolines and dichloroquinoxalines with a range of aliphatic, allylic, benzylic and saturated (hetero)cyclic magnesium amides in the presence of lithium chloride as additive. The reactions were performed at 50 °C in THF and led to the desired aminated products in 56–96% yield.