Biomechanical Modulation Therapy-A Stem Cell Therapy Without Stem Cells for the Treatment of Severe Ocular Burns.
Biomechanical Modulation Therapy-A Stem Cell Therapy Without Stem Cells for the Treatment of Severe Ocular Burns.
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DOI：
10.1167/tvst.9.12.5
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发表时间：
2020-11
影响因子：
3
通讯作者：
Connon CJ
中科院分区：
文献类型：
--
作者：
Gouveia RM;Connon CJ
由化学和热烧伤引起的眼部损伤通常无法控制，并且经常导致毁容、角膜混浊/混浊和视力丧失。目前，有相当数量的外科和药理学方法可用于治疗急性或慢性阶段的此类损伤。然而，这些现有的干预措施主要针对（并且限于）抑制角膜炎症和新生血管形成，同时促进上皮再形成。在上皮愈合严重受损的情况下，例如由于角膜缘干细胞缺乏，眼表重建是一种合适的但最后的选择。在这篇简要的综述中，我们讨论了生物力学调制疗法（BMT）如何通过恢复角膜缘干细胞龛来促进受烧伤影响的眼组织再生。具体来说，支持这种新的治疗方式的科学依据进行了描述，沿着我们越来越多的理解，组织生物力学在干细胞的命运和功能中发挥的作用。还进一步讨论了BMT作为未来治疗选择的潜在影响，用于管理影响组织顺应性的损伤。
Ocular injuries caused by chemical and thermal burns are often unmanageable and frequently result in disfigurement, corneal haze/opacification, and vision loss. Currently, a considerable number of surgical and pharmacological approaches are available to treat such injuries at either an acute or a chronic stage. However, these existing interventions are mainly directed at (and limited to) suppressing corneal inflammation and neovascularization while promoting re-epithelialization. Reconstruction of the ocular surface represents a suitable but last-option recourse in cases where epithelial healing is severely impaired, such as due to limbal stem cell deficiency. In this concise review, we discuss how biomechanical modulation therapy (BMT) may represent a more effective approach to promoting the regeneration of ocular tissues affected by burn injuries via restoration of the limbal stem cell niche. Specifically, the scientific basis supporting this new therapeutic modality is described, along with our growing understanding of the role that tissue biomechanics plays in stem cell fate and function. The potential impact of BMT as a future treatment option for the management of injuries affecting tissue compliance is also further discussed.
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影响因子：
3.7
作者：
Allen CL;Clare G;Stewart EA;Branch MJ;McIntosh OD;Dadhwal M;Dua HS;Hopkinson A
通讯作者：
Hopkinson A
DOI：
10.1111/wrr.12432
发表时间：
2016-05
期刊：
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
影响因子：
--
作者：
Chiang RS;Borovikova AA;King K;Banyard DA;Lalezari S;Toranto JD;Paydar KZ;Wirth GA;Evans GR;Widgerow AD
通讯作者：
Widgerow AD
影响因子：
9.7
作者：
Figueiredo GS;Bojic S;Rooney P;Wilshaw SP;Connon CJ;Gouveia RM;Paterson C;Lepert G;Mudhar HS;Figueiredo FC;Lako M
通讯作者：
Lako M
DOI：
10.1007/s00417-011-1760-3
发表时间：
2011-11-01
影响因子：
2.7
作者：
Han, Eui Seok;Wee, Won Ryang;Kim, Mee Kum
通讯作者：
Kim, Mee Kum
影响因子：
3.4
作者：
Bongiorno, Tom;Chojnowski, Jena L.;Sulchek, Todd
通讯作者：
Sulchek, Todd