Investigation of three-surface properties of several metals and their relation to blood compatibility.
Investigation of three-surface properties of several metals and their relation to blood compatibility.
复制标题
研究几种金属的三表面特性及其与血液相容性的关系。
DOI：
10.1002/jbm.820060406
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
Akira Furuse
中科院分区：
文献类型：
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作者：
V. Depalma;Robert E. Baier;J. Ford;Vincent L. Gott;Akira Furuse
制备5种金属的无有机物试样，并通过参数表征，这些参数指示它们的相对表面电荷、表面纹理和表面能，然后评价它们的抗血栓性程度。对于所研究的材料，当将标准人工瓣膜环置于犬下腔静脉中时，植入前静息电位与最终抗血栓性之间没有预测相关性。表面结构的不均匀性大于1微米左右，这就必然会形成血栓。植入后，假体环管腔上存在薄的、不稳定的蛋白质存款与“高能”材料对血栓积聚的钝化之间存在正相关性。持续钝化的金属，316不锈钢和钨铬钴合金21，通过在植入后2小时内获得有机膜而动态地钝化。在新鲜流动的血液中持续停留期间，这些金属最终被低临界表面张力的明显单分散蛋白质组分所支配。当使用具有与金属相似的初始表面性质但缺乏反应性和腐蚀性的抗血栓热解碳作为比较标准时，这些发现得到了证实。
Organic-free specimens of 5 metals were prepared and characterized by parameters indicating their relative surface charge, surface texture, and surface energy prior to evaluation of their degree of thromboresistance. For the materials studied, there was no predictive correlation between the pre-implatation electrical rest potentials and ultimate thromboresistance when standard prosthetic rings were placed in the canine inferior vena cava. Surface textural inhomogeneities greater thatn a micrometer or so made thrombus formation a certainty. There was a positive postimplantation correlation between the presence of a thin, labile, proteinaceous deposit on the prosthetic ring lumens and the passivation of the “high-energy” materials towards thrombus accumulation. The metals which did consistently passivate, 316 Stainless Steel and Stellite 21, did so dynamically by acquiring an organic film within 2 hr after implantation. During continued residence in fresh, flowing blood these metals ultimately became dominated by an apparently monodisperse protein component of low critical surface tension. These findings were confirmed when thromboresistant pyrolytic carbon having initial surface properties similar to the metals but lacking reactivity and corrosivity was used as a comparison standard.