Post-colonoscopic Listeria septicemia in ulcerative colitis during immunosuppressive therapy
Post-colonoscopic Listeria septicemia in ulcerative colitis during immunosuppressive therapy
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DOI：
10.2169/internalmedicine.46.0303
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发表时间：
2007-01-01
影响因子：
1.2
通讯作者：
Goto, Hidemi
中科院分区：
文献类型：
--
作者：
Minami, Masaaki;Hasegawa, Tadao;Goto, Hidemi
一名78岁的男子谁被诊断为溃疡性结肠炎是因为不受控制的严重，频繁，出血性腹泻入院。患者接受免疫抑制治疗，包括皮质类固醇和硫唑嘌呤。使用结肠镜检查来评估疾病活动度。这表明他从直肠到回肠的消化道粘膜受到了损害。他在结肠镜检查后不久就发高烧。血培养显示单核细胞增生李斯特菌。治疗改为静脉注射氨苄青霉素20天。他的一般身体症状，包括带血腹泻，在治疗后有所改善。我们推测此病例可能是因为肠镜检查导致细菌移位而引起单核细胞增生李斯特菌败血症。
A 78-year-old man who had been diagnosed with ulcerative colitis was admitted because of uncontrolled severe, frequent, bloody diarrhea. He was treated with immunosuppressive therapy that included corticosteroid and azathioprine. Colonoscopy was used to assess disease activity. This revealed that the mucosa of his digestive tract from the rectum to the ileum was damaged. He developed a high-grade fever soon after colonoscopy. Blood culture demonstrated Listeria monocytogenes. Treatment was changed to intravenous ampicillin for 20 days. His general body symptoms, including the bloody diarrhea, improved after treatment. We assume that the colonoscopy induced Listeria monocytogenes septicemia through bacterial translocation in this patient.