The role of cGMP-signalling and calcium-signalling in photoreceptor cell death: perspectives for therapy development.
The role of cGMP-signalling and calcium-signalling in photoreceptor cell death: perspectives for therapy development.
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CGMP信号和钙信号在光感受器细胞死亡中的作用：治疗发展的前景。
DOI：
10.1007/s00424-021-02556-9
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Paquet-Durand F
中科院分区：
文献类型：
--
作者：
Das S;Chen Y;Yan J;Christensen G;Belhadj S;Tolone A;Paquet-Durand F
第二信使，cGMP和Ca2+，都与视网膜变性有关；然而，目前尚不清楚两者中哪一个与感光细胞死亡最相关。光感受器中cgmp信号和钙（Ca2+）信号之间的密切联系和串扰加剧了这一问题。在这篇综述中，我们总结了cgmp信号传导和Ca2+信号传导与遗传性光感受器变性相关的关键方面。涵盖的主题包括cgmp信号靶点，Ca2+可渗透通道的作用，与能量代谢的关系，calpain型蛋白酶，以及相关代谢过程如何触发和执行光感受器细胞死亡。然后重点放在cGMP依赖的机制，以及超高的光感受器cGMP水平如何在运动级联Ca2+依赖和独立过程中设置，最终导致光感受器细胞死亡。最后，展望了利用cgmp信号传导的特定特征的非突变治疗方法。这些方法可能与合适的药物输送系统相结合，转化为临床应用。
The second messengers, cGMP and Ca2+, have both been implicated in retinal degeneration; however, it is still unclear which of the two is most relevant for photoreceptor cell death. This problem is exacerbated by the close connections and crosstalk between cGMP-signalling and calcium (Ca2+)-signalling in photoreceptors. In this review, we summarize key aspects of cGMP-signalling and Ca2+-signalling relevant for hereditary photoreceptor degeneration. The topics covered include cGMP-signalling targets, the role of Ca2+ permeable channels, relation to energy metabolism, calpain-type proteases, and how the related metabolic processes may trigger and execute photoreceptor cell death. A focus is then put on cGMP-dependent mechanisms and how exceedingly high photoreceptor cGMP levels set in motion cascades of Ca2+-dependent and independent processes that eventually bring about photoreceptor cell death. Finally, an outlook is given into mutation-independent therapeutic approaches that exploit specific features of cGMP-signalling. Such approaches might be combined with suitable drug delivery systems for translation into clinical applications.
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DOI：
10.1186/1478-811x-8-31
发表时间：
2010-12-22
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
Chaitanya GV;Steven AJ;Babu PP
通讯作者：
Babu PP
影响因子：
5.5
作者：
Duan, Yuntao;Gross, Robert A.;Sheu, Shey-Shing
通讯作者：
Sheu, Shey-Shing
影响因子：
1.8
作者：
Bertelsen, Mette;Jensen, Hanne;Rosenberg, Thomas
通讯作者：
Rosenberg, Thomas
影响因子：
--
作者：
Dutt P;Croall DE;Arthur JS;Veyra TD;Williams K;Elce JS;Greer PA
通讯作者：
Greer PA
影响因子：
5.3
作者：
Azam, M;Andrabi, SS;Chishti, AH
通讯作者：
Chishti, AH