Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer's disease.
Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer's disease.
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对 181 名阿尔茨海默病患者的抑郁、激越和精神病症状的纵向评估。
DOI：
10.1176/ajp.153.11.1438
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Carta,A
中科院分区：
文献类型：
--
作者：
Levy,ML;Cummings,JL;Fairbanks,LA;Bravi,D;Calvani,M;Carta,A
方法对181例可能为阿尔茨海默病的患者进行为期3个月的神经精神症状评定。结果1年内神经精神症状的复发率为85%，与对照组比较，差异有统计学意义（P < 0. 05）。93%的人情绪激动95%的人精神错乱任何时间点的症状频率都低估了累积的1年频率。有多种症状的患者复发率明显更高。女性比男性表现出更多的症状。年龄最大组（76-87岁）的患者精神病较多，抑郁和激越较少，认知能力下降较慢。精神病与更快的认知能力下降，和搅拌与更快的功能恶化。ConclusionsThese结果表明，一旦精神症状存在于阿尔茨海默病患者，他们经常复发。这些症状随年龄、性别和疾病进展速度而变化。
ObjectiveThe goal of this study was to define the recurrence or continuation of neuropsychiatric symptoms in patients with Alzheimer's disease who were observed serially for a 1-year period.MethodOne hundred eighty-one patients with probable Alzheimer's disease were assessed five times at 3-month intervals with a standardized neuropsychiatric rating instrument.ResultsRecurrence rates of neuropsychiatric symptoms during the 1-year period were 85% for depression, 93% for agitation, and 95% for psychosis. Symptom frequency at any point in time underestimated the cumulative 1-year frequency. Recurrence rates were significantly greater among patients who had multiple symptoms. Women exhibited more symptoms than men. Patients in the oldest age group (76-87 years) had more psychosis, less depression and agitation, and slower cognitive decline. Psychosis was associated with more rapid cognitive decline, and agitation was associated with more rapid functional deterioration.ConclusionsThese results indicate that once psychiatric symptoms are present in patients with Alzheimer's disease, they frequently recur. These symptoms vary with age, sex, and rate of illness progression.