Studies directed toward the total synthesis of discodermolide: Asymmetric synthesis of the C1-C14 fragment
Studies directed toward the total synthesis of discodermolide: Asymmetric synthesis of the C1-C14 fragment
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DOI：
10.1021/ol026139r
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发表时间：
2002-07-11
期刊：
影响因子：
5.2
通讯作者：
Panek, JS
中科院分区：
文献类型：
--
作者：
Arefolov, A;Panek, JS
[图谱]海洋天然产物（+）-discodermolide的C1-C14亚基的会聚和立体选择性组装已经完成。该方法采用手性烯丙基硅烷键的建设方法，建立四个八个立体中心。通过C1-C6和C7-C14亚基之间的有效立体选择性乙酸酯羟醛缩合反应实现关键片段偶联。
[GRAPHICS]A convergent and stereoselective assembly of the C1-C14 subunit of marine natural product (+)-discodermolide has been completed. The approach employs chiral allylsilane bond construction methodology to establish four of the eight stereogenic centers. Key fragment coupling is achieved via an efficient stereoselective acetate aldol reaction between C1-C6 and C7-C14 subunits.