Zyxin is upregulated in the nucleus by thymosin β4 in SiHa cells
Zyxin is upregulated in the nucleus by thymosin β4 in SiHa cells
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DOI：
10.1016/j.yexcr.2006.07.021
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发表时间：
2006-10-15
影响因子：
3.7
通讯作者：
Cha, Hee-Jae
中科院分区：
文献类型：
--
作者：
Moon, Hye-Sung;Even-Ram, Sharona;Cha, Hee-Jae
胸腺素β4是一种43个氨基酸的肌动蛋白结合蛋白，促进细胞迁移，在血管生成、伤口愈合和肿瘤转移中起重要作用。我们搜索了胸腺素β4上调的基因，并发现在外源添加胸腺素β4的情况下，以及当胸腺素β4在腺病毒载体中过表达时，SIHA细胞中的凝乳素增加。凝集素和胸腺肽β4在细胞核内的定位增加。我们的结论是胸腺素β4可能通过增加凝集素的表达而发挥其部分促进迁移的活性。由爱思唯尔公司出版。
Thymosin beta 4 is a 43-amino acid actin-binding protein that promotes cell migration and is important in angiogenesis, wound healing, and tumor metastasis. We searched for genes upregulated by thymosin beta 4 and identified zyxin as increased in SiHa cells in the presence of exogenously added thymosin beta 4 and when thymosin beta 4 is overexpressed using adenoviral vectors. Both zyxin and thymosin beta 4 show increased localization in the nucleus. We conclude that thymosin beta 4 may exert some of its migration promoting activity via increased zyxin expression. Published by Elsevier Inc.