Common genetic variation near MC4R is associated with waist circumference and insulin resistance
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
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DOI：
10.1038/ng.156
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发表时间：
2008-06-01
期刊：
影响因子：
30.8
通讯作者：
Kooner, Jaspal S.
中科院分区：
文献类型：
--
作者：
Chambers, John C.;Elliott, Paul;Kooner, Jaspal S.
我们在2684名印度裔亚洲人中针对胰岛素抵抗及相关表型进行了一项全基因组关联研究（318237个单核苷酸多态性），并在11955名印度裔亚洲人或欧洲血统的个体中进行了进一步检测。我们发现黑素皮质素4受体（MC4R）附近的rs12970134与腰围（P = 1.7×10⁻⁹）相关，并且独立地与胰岛素抵抗相关。rs12970134风险等位基因的纯合子腰围增加约2厘米。MC4R附近的常见基因变异与肥胖和胰岛素抵抗的风险相关。
We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian Asian or European ancestry. We found associations of rs12970134 near MC4R with waist circumference (P = 1.7 x 10(-9)) and, independently, with insulin resistance. Homozygotes for the risk allele of rs12970134 have similar to 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance.