Interventions in the initial prodromal states of psychosis in Germany:: concept and recruitment
Interventions in the initial prodromal states of psychosis in Germany:: concept and recruitment
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DOI：
10.1192/bjp.187.48.s45
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发表时间：
2005-08-01
影响因子：
10.5
通讯作者：
Klosterkötter, J
中科院分区：
文献类型：
--
作者：
Bechdolf, A;Ruhrmann, S;Klosterkötter, J
德国精神分裂症研究网络（GRNS）的早期发现和干预计划以多维方法研究精神病的初始前驱期。两个干预策略正在研究两个大规模的多中心projects.Aims提出的概念的干预研究，并提供一个临时报告的招聘procedure.Method全面的认知行为疗法已开发的早期初始前驱状态的患者。对于“晚期初始前驱状态”的患者，探索非典型抗精神病药氨磺必利。这两种干预措施进行了评估，在随机对照试验中使用临床管理作为对照condition.Results之间的2001年1月和2003年3月，1212个人寻求帮助的心理健康问题进行了筛选推定的前驱症状在四所大学的中心。超过388个人符合标准的干预措施和188（48.5%）给予知情同意参加trials.Conclusions的筛选程序似乎是可行的，试验参与似乎是可以接受的相关比例的人在发展精神病的风险增加。
Background The Early Detection and Intervention Programme of the German Research Network on Schizophrenia (GRNS) investigates the initial prodromal phase of psychosis in a multidimensional approach. Two intervention strategies are being studied by two large-scale multicentre projects.Aims To present the concept of the intervention studies, and to provide an interim report of the recruitment procedure.Method Comprehensive cognitive behavioural therapy has been developed for patients in the early initial prodromal state'. For patients in the 'late initial prodromal state' the atypical neuroleptic amisulpride is explored. Both interventions are evaluated in randomised controlled trials using clinical management as the control condition.Results Between January 2001 and March 2003, 1212 individuals seeking help for mental health problems were screened for putative prodromal symptoms at four university centres. More than 388 individuals fulfilled criteria for both interventions and 188 (48.5%) gave informed consent to participate in the trials.Conclusions The screening procedure appears to be feasible and trial participation seems to be acceptable to a relevant proportion of people at increased risk of developing psychosis.