COLLOIDAL MAGNETIC-RESONANCE CONTRAST AGENTS - EFFECT OF PARTICLE SURFACE ON BIODISTRIBUTION
COLLOIDAL MAGNETIC-RESONANCE CONTRAST AGENTS - EFFECT OF PARTICLE SURFACE ON BIODISTRIBUTION
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DOI：
10.1016/0304-8853(93)91115-n
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发表时间：
1993-04-01
影响因子：
2.7
通讯作者：
BRADY, TJ
中科院分区：
文献类型：
--
作者：
PAPISOV, MI;BOGDANOV, A;BRADY, TJ
葡聚糖涂层的超顺磁性颗粒的表面结构作为生物分布的定义因素进行了研究。胶体粒子和聚合物分子具有相同的大小和相似的外部结构，具有相似的生物活性和生物分布。颗粒表面上的致密葡聚糖层被鉴定为负责淋巴结中颗粒积聚的结构。
Surface structure of dextran-coated superparamagnetic particles is studied as a biodistribution-defining factor. Colloidal particle and polymer molecule of the same size and similar outer structure are shown to possess similar biokinetics and biodistribution. A dense dextran layer on the particle surface is identified as a structure responsible for particle accumulation in the lymph nodes.