Enhanced peripheral vasodilation in humans after a fatty meal
Enhanced peripheral vasodilation in humans after a fatty meal
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DOI：
10.1016/s0735-1097(00)00758-0
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发表时间：
2000-08-01
影响因子：
24
通讯作者：
Celermajer, DS
中科院分区：
文献类型：
--
作者：
Raitakari, OT;Lai, N;Celermajer, DS
目的 我们试图研究脂肪餐对血管反应性的影响，包括内皮功能和最大血管舒张。 背景 最近关于进食脂肪餐后外周脉管系统生理变化的报道一直存在争议。 方法 对 12 名志愿者在食用富含饱和脂肪酸的高脂餐（1030 kcal，61 g 脂肪）之前、之后 3 小时和之后 6 小时进行研究，其中 10在吃了富含单不饱和脂肪酸的类似膳食后重新研究。使用超声评估肱动脉中的血流介导的扩张（FMD）来评估内皮功能。在上臂缺血 5 分钟之前和之后每 10 至 15 秒，使用静脉闭塞应变计体积描记法记录静息和缺血后前臂血流量 (FBF)。 结果 肱动脉基底直径、静息 FBF 和缺血后充血在高脂肪肉类后增加（均 p < 0.001），而 FMD 没有变化。静息 FBF 的增加与餐后胰岛素（r = 0.80，p < 0.002）和甘油三酯（r = 0.77，p < 0.005）水平的增加相关。结论我们得出的结论是，吃脂肪餐会引起血管舒张并增加静息和刺激的 FBF，并且这些观察结果可能是由餐后胰岛素和/或甘油三酯水平的变化介导的。餐后发生的代谢变化与导管动脉中内皮一氧化氮释放受损无关，(C) 2000，美国心脏病学会。
OBJECTIVES We sought to study the effects of a fatty meal on vascular reactivity, including endothelial function and maximal vasodilation.BACKGROUND Recent reports regarding the physiological changes in peripheral vasculature after eating a fatty meal have been controversial.METHODS Twelve volunteers were studied before, 3 h after, and 6 h after a high-fat meal (1030 kcal, 61 g fat) rich in saturated fatty acids, and 10 were restudied after a similar meal rich in monounsaturated fatty acids. Endothelial function was assessed as flow-mediated dilatation (FMD) in the brachial artery using ultrasound. Resting and postischemic forearm blood flow (FBF) were recorded using venous occlusion strain-gauge plethysmography, before, and every 10 to 15 s after, 5 min upper arm ischemia.RESULTS Brachial artery basal diameter, resting FBF and postischemic hyperemia increased after high-fat meats (all p < 0.001), whereas FMD did not change. The increase in resting FBF correlated with increases in postprandial insulin (r = 0.80, p < 0.002) and triglyceride (r = 0.77, p < 0.005) levels.CONCLUSIONS We concluded that eating a fatty meal induces vasodilation and increases resting and stimulated FBF and that these observations are probably mediated by postprandial changes in insulin and/or triglyceride levels. The metabolic changes that occur after meals are not associated with impaired endothelial nitric oxide release in the conduit arteries, (C) 2000 by the American College of Cardiology.