A systematic review of antiretroviral adherence interventions for HIV-infected people who use drugs.
A systematic review of antiretroviral adherence interventions for HIV-infected people who use drugs.
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DOI：
10.1007/s11904-012-0134-8
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发表时间：
2012-12
影响因子：
4.6
通讯作者：
Altice, Frederick L.
中科院分区：
文献类型：
--
作者：
Binford, Meredith Camp;Kahana, Shoshana Y.;Altice, Frederick L.
关键词：
吸毒的 HIV 感染者 (PWUD) 特别容易因联合抗逆转录病毒治疗 (cART) 依从性不佳而受到影响。对提高 HIV 感染 PWUD 的 cART 依从性和病毒学结果的干预措施进行了系统评价。在 45 项符合条件的研究中，随机对照试验表明，直接施用抗逆转录病毒治疗、药物辅助治疗 (MAT)、应急管理和护士提供的多成分干预措施可显着改善短期依从性和病毒学结果，但这些效果在干预停止后并未持续。队列研究和前瞻性研究表明短期内 cART 与 MAT 的依从性有所提高。需要更多关于使用认知行为疗法、动机访谈、同伴驱动的干预措施以及将 MAT 纳入 HIV 临床护理对 cART 依从性和 HIV 治疗结果的功效的结论性数据。令人非常担忧的是，实际上缺乏具有持续的干预后依从性和病毒学益处的干预措施。讨论了未来的研究方向，包括开发促进长期改善依从性和病毒学结果的干预措施。
HIV-infected persons who use drugs (PWUDs) are particularly vulnerable for suboptimal combination antiretroviral therapy (cART) adherence. A systematic review of interventions to improve cART adherence and virologic outcomes among HIV-infected PWUDs was conducted. Among the 45 eligible studies, randomized controlled trials suggested directly administered antiretroviral therapy, medication-assisted therapy (MAT), contingency management, and multi-component, nurse-delivered interventions provided significant improved short-term adherence and virologic outcomes, but these effects were not sustained after intervention cessation. Cohort and prospective studies suggested short-term increased cART adherence with MAT. More conclusive data regarding the efficacy on cART adherence and HIV treatment outcomes using cognitive behavioral therapy, motivational interviewing, peer-driven interventions and the integration of MAT into HIV clinical care are warranted. Of great concern was the virtual lack of interventions with sustained post-intervention adherence and virologic benefits. Future research directions, including the development of interventions that promote long-term improvements in adherence and virologic outcomes, are discussed.
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影响因子：
3.8
作者：
Deeks, SG;Grant, RM;Petropoulos, CJ
通讯作者：
Petropoulos, CJ
影响因子：
5.4
作者：
Broadhead, RS;Heckathorn, DD;Selwyn, PA
通讯作者：
Selwyn, PA
DOI：
10.1016/s0140-6736(10)60829-x
发表时间：
2010-07-31
期刊：
Lancet (London, England)
影响因子：
--
作者：
Altice FL;Kamarulzaman A;Soriano VV;Schechter M;Friedland GH
通讯作者：
Friedland GH
影响因子：
4.2
作者：
Azar, Marwan M.;Springer, Sandra A.;Meyer, Jaimie P.;Altice, Frederick L.
通讯作者：
Altice, Frederick L.
影响因子：
2
作者：
Cunningham CO;Sohler NL;Cooperman NA;Berg KM;Litwin AH;Arnsten JH
通讯作者：
Arnsten JH