Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases.
Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases.
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DOI：
10.1101/cshperspect.a003020
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发表时间：
2009-09
影响因子：
7.2
通讯作者：
Takashi Watanabe;Kazuhide Sato;K. Kaibuchi
中科院分区：
文献类型：
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作者：
Takashi Watanabe;Kazuhide Sato;K. Kaibuchi
上皮形成物理屏障，将身体的内部环境与外部环境分开。功能性上皮细胞的生物发生需要许多细胞过程的精确协调。上皮生物发生中的关键事件之一是建立依赖于钙粘蛋白的细胞-细胞接触，其启动形态学变化和其他粘附结构的形成。钙粘蛋白介导的粘附产生细胞内信号，控制细胞骨架重组，极性和囊泡运输。在这些信号通路中，涉及小GTP酶的那些在上皮生物发生中起关键作用。E-钙粘蛋白的组装激活几种小GTP酶，反过来，激活的小GTP酶控制E-钙粘蛋白介导的粘附对上皮生物发生的影响。在这里，我们专注于在E-钙粘蛋白介导的上皮连接的小GTdR信号。
Epithelia form physical barriers that separate the internal milieu of the body from its external environment. The biogenesis of functional epithelia requires the precise coordination of many cellular processes. One of the key events in epithelial biogenesis is the establishment of cadherin-dependent cell-cell contacts, which initiate morphological changes and the formation of other adhesive structures. Cadherin-mediated adhesions generate intracellular signals that control cytoskeletal reorganization, polarity, and vesicle trafficking. Among such signaling pathways, those involving small GTPases play critical roles in epithelial biogenesis. Assembly of E-cadherin activates several small GTPases and, in turn, the activated small GTPases control the effects of E-cadherin-mediated adhesions on epithelial biogenesis. Here, we focus on small GTPase signaling at E-cadherin-mediated epithelial junctions.