Neonatal genetic epilepsies display convergent white matter microstructural abnormalities.
Neonatal genetic epilepsies display convergent white matter microstructural abnormalities.
复制标题
新生儿遗传性癫痫表现出聚合性白质微结构异常。
DOI：
10.1111/epi.16735
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发表时间：
2020
期刊：
影响因子：
5.6
通讯作者：
Knowles,JulietK
中科院分区：
文献类型：
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作者：
SandovalKaramian,AmandaG;Wusthoff,CourtneyJ;Boothroyd,Derek;Yeom,KristenW;Knowles,JulietK
白色物质在新生儿期迅速发育。其结构在发育期间和之后受到神经元活动的影响。病理性神经元活动（例如癫痫发作）可能会改变白色物质，这反过来可能导致网络功能障碍。新生儿癫痫为研究癫痫发作和早期白色物质发育提供了机会。我们的目的是确定在没有脑损伤或先天性异常的情况下新生儿癫痫发作是否与白色微结构改变有关。在这项针对足月新生儿的回顾性病例对照研究中，病例确诊或疑似遗传性癫痫，脑部磁共振成像（MRI）正常，无其他独立影响白色物质的疾病。对照组为MRI结果正常的健康新生儿。通过定量平均扩散率（MD）评估白色物质微观结构。在22例病例中，与22例对照组相比，在MRI上控制胎龄和经后年龄，胼胝体周围的MD显著较低。这一发现表明聚合异常胼胝体显微结构在新生儿癫痫与各种可疑的遗传原因。需要进一步研究以确定新生儿癫痫发作相关异常白色物质（一种潜在的致病机制）的具体性质、原因和功能影响。
White matter undergoes rapid development in the neonatal period. Its structure during and after development is influenced by neuronal activity. Pathological neuronal activity, as in seizures, might alter white matter, which in turn may contribute to network dysfunction. Neonatal epilepsy presents an opportunity to investigate seizures and early white matter development. Our objective was to determine whether neonatal seizures in the absence of brain injury or congenital anomalies are associated with altered white matter microstructure. In this retrospective case‐control study of term neonates, cases had confirmed or suspected genetic epilepsy and normal brain magnetic resonance imaging (MRI) and no other conditions independently impacting white matter. Controls were healthy neonates with normal MRI results. White matter microstructure was assessed via quantitative mean diffusivity (MD). In 22 cases, MD was significantly lower in the genu of the corpus callosum, compared to 22 controls, controlling for gestational age and postmenstrual age at MRI. This finding suggests convergent abnormal corpus callosum microstructure in neonatal epilepsies with diverse suspected genetic causes. Further study is needed to determine the specific nature, causes, and functional impact of seizure‐associated abnormal white matter in neonates, a potential pathogenic mechanism.