Thalamocortical functional connectivity in infants with prenatal opioid exposure correlates with severity of neonatal opioid withdrawal syndrome.
Thalamocortical functional connectivity in infants with prenatal opioid exposure correlates with severity of neonatal opioid withdrawal syndrome.
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产前阿片类药物暴露婴儿的丘脑皮质功能连接与新生儿阿片类药物戒断综合征的严重程度相关。
DOI：
10.1007/s00234-022-02939-4
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发表时间：
2022
期刊：
影响因子：
2.8
通讯作者：
Sadhasivam,Senthilkumar
中科院分区：
文献类型：
--
作者：
Radhakrishnan,Rupa;Vishnubhotla,RamanaV;Guckien,Zoe;Zhao,Yi;Sokol,GregoryM;Haas,DavidM;Sadhasivam,Senthilkumar
产前阿片类药物暴露（POE）是一个日益增长的公共卫生问题，由于其相关的不良后果，包括新生儿阿片类药物戒断综合征（NOWS）。本研究的目的是评估丘脑功能连接的改变，在新生儿与POE使用静息态功能磁共振成像（rs-fMRI），并确定这些改变连接措施是否与NOWS severity.MethodsIn这一前瞻性，IRB批准的研究，我们进行了rs-fMRI在19个婴儿与POE和20个健康对照婴儿没有POE。在标准的预处理之后，我们以右侧和左侧丘脑作为感兴趣的区域进行了基于种子的功能连接分析。我们在产前阿片类药物暴露组进行事后分析，以确定改变丘脑皮质连接与NOWS. P值<0.05的严重程度的关联被认为是statistically significant.ResultsThere有几个地区的显着改变丘脑皮质功能连接的婴儿与POE相比，健康的婴儿。丘脑皮质功能连接的不同区域与最大改良Finnegan评分相关。NOWS的丘脑皮质连接和严重程度之间的关联名义上修改了产妇的心理条件和polysubstance use.ConclusionOur研究结果揭示产前阿片类药物依赖相关的改变，在婴儿大脑中的丘脑功能连接与NOWS的严重程度。 未来的研究可能会受益于评估丘脑皮质静息状态功能连接的婴儿与POE，以帮助分层的长期神经发育结果的风险。
PurposePrenatal opioid exposure (POE) is a growing public health concern due to its associated adverse outcomes including neonatal opioid withdrawal syndrome (NOWS). The aim of this study was to assess alterations in thalamic functional connectivity in neonates with POE using resting-state functional magnetic resonance imaging (rs-fMRI) and identify whether these altered connectivity measures were associated with NOWS severity.MethodsIn this prospective, IRB-approved study, we performed rs-fMRI in 19 infants with POE and 20 healthy control infants without POE. Following standard pre-processing, we performed seed-based functional connectivity analysis with the right and left thalamus as the regions of interest. We performed post hoc analysis in the prenatal opioid exposure group to identify associations of altered thalamocortical connectivity with severity of NOWS.Pvalue of < .05 was considered statistically significant.ResultsThere were several regions of significantly altered thalamic to cortical functional connectivity in infants with POE compared to the healthy infants. Distinct regions of thalamocortical functional connectivity correlated with maximum modified Finnegan score. Association between thalamocortical connectivity and severity of NOWS was nominally modified by maternal psychological conditions and polysubstance use.ConclusionOur findings reveal prenatal opioid exposure-related alterations in thalamic functional connectivity in the infant brain that are correlated with severity of NOWS. Future studies may benefit from evaluation of thalamocortical resting state functional connectivity in infants with POE to help stratify risk of long term neurodevelopmental outcomes.