Circadian modulation of QT rate dependence in healthy volunteers - Gender and age differences
Circadian modulation of QT rate dependence in healthy volunteers - Gender and age differences
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DOI：
10.1016/s0022-0736(99)90019-5
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发表时间：
1999-01-01
影响因子：
1.3
通讯作者：
Coumel, P
中科院分区：
文献类型：
--
作者：
Extramiana, F;Maison-Blanche, P;Coumel, P
已知QT频率依赖性与自主神经张力的昼夜变化和性别有关。然而，年龄和心率变异性（HRV）的影响还没有得到很好的建立。60名健康受试者（男性30名）分为3组（第1组，20-29岁;第2组，30-39岁;第3组，40-50岁），分别在白天和夜间进行24小时心电图QT/RR关系的测定。在白天，两种性别的QT频率依赖性较大。女性表现出更强的QT频率依赖性（白天为0.195，男性为0.154，P <0.0001）。昼夜节律调节随年龄的增加而降低（昼夜斜率差异：第1组，0.038;第2组，0.031;第3组，0.001;方差分析P <0.05）。此外，QT频率依赖性随着平均RR降低而增加（r =-0.58，P < .0001），随着HRV参数增加而降低。可以发现对QT频率依赖性的多种影响：不仅是昼夜节律和性别调节，而且还有年龄，心率和HRV干预。
QT rate dependence is known to be linked with both circadian variations of the autonomic tone and gender. However, age and heart rate variability (HRV) influences are not well established. The QT/RR relationship was evaluated, separately during the day and at night, on 24-hour electrocardiogram in 60 healthy subjects (30 men) divided into three homogeneous groups (group 1, 20-29; group 2 30-39; group 3, 40-50 years). QT rate dependence was larger during the day in both genders. Women showed stronger QT rate dependence (0.195 during the day vs 0.154 in men P < .0001). The circadian modulation decreased with increasing age (day/night slope differences: group 1, 0.038; group 2, 0.031; group 3, 0.001; analysis of variance P < .05). In addition, QT rate dependence increased as mean RR decreased (r = -0.58, P < .0001) and decreased as HRV parameters increased. Multiple influences on QT rate dependence can be found: not only circadian and gender modulation, but also age, heart rate, and HRV interventions.