Systemic magnesium to improve quality of post-surgical recovery in outpatient segmental mastectomy: a randomized, double-blind, placebo-controlled trial
Systemic magnesium to improve quality of post-surgical recovery in outpatient segmental mastectomy: a randomized, double-blind, placebo-controlled trial
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DOI：
10.1684/mrh.2014.0349
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发表时间：
2013-10-01
影响因子：
3.2
通讯作者：
McCarthy, Robert J.
中科院分区：
文献类型：
--
作者：
De Oliveira, Gildasio S.;Bialek, Jane;McCarthy, Robert J.
背景资料：围手术期全身镁是否能改善门诊手术患者术后恢复质量仍有待确定。本研究的主要目的是评估全身镁对门诊乳房部分切除术患者术后恢复质量的影响。方法：本研究是一项前瞻性、随机、双盲、安慰剂对照的临床试验。女性受试者随机接受静脉注射镁（在麻醉诱导前15分钟内在100 mL生理盐水中注射50 mg/kg MgSO 4，随后以15 mg/kg/h的速度输注）或相同体积的生理盐水。主要结局是术后24小时的恢复质量40（QOR-40）问卷。结果：50名受试者被招募，46人完成了研究。镁组患者的总体恢复质量评分优于生理盐水组，中位差异为24（99%CI，3 - 33），P
Background: It remains to be determined if perioperative systemic magnesium can improve postoperative quality of recovery of patients undergoing ambulatory procedures. The main objective of the current investigation was to evaluate the effect of systemic magnesium on postoperative quality of recovery in patients undergoing outpatient segmental mastectomies. Methods: The study was a prospective randomized, double-blind, placebo-controlled, clinical trial. Female subjects were randomized to receive intravenous magnesium (MgSO4 50mg/kg in 100 mL of normal saline over 15 min before anesthesia induction, followed by an infusion of 15 mg/kg/hour) or the same volume of saline. The primary outcome was the Quality of Recovery 40 (QOR-40) questionnaire at 24 hours after surgery. Results: 50 subjects were recruited and 46 completed the study. Patients in the magnesium group had better global Quality of Recovery scores compared with the saline group, with a median difference of 24 (99% CI, 3 to 33), P