Epithelial sodium channel (ENaC) and the control of blood pressure
Epithelial sodium channel (ENaC) and the control of blood pressure
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DOI：
10.1016/j.coph.2013.11.010
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发表时间：
2014-04-01
影响因子：
4
通讯作者：
Rossier, Bernard C.
中科院分区：
文献类型：
--
作者：
Rossier, Bernard C.
阿米洛利敏感上皮钠通道（ENaC）构成了肾小管远端、结肠远端、几个外分泌腺管和肺上皮细胞钠重吸收的限速步骤。该通道的活性受醛固酮和参与维持钠平衡、血容量和血压的激素的调节。在这篇综述中，我们讨论了ENaC的功能和调控与钠平衡和血压的控制的最新进展。新的药物靶点的确定将有助于开发下一代利尿剂和治疗高血压的新疗法。
The amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. The activity of this channel is regulated by aldosterone and hormones involved in the maintenance of sodium balance, blood volume and blood pressure. In this review, we discuss recent advances in our understanding of ENaC function and regulation relevant to the control of sodium balance and blood pressure. The identification of novel drug targets should help in the development of the next generation of diuretics and of new therapies for the treatment of hypertension.