The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis.
The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis.
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DOI：
10.1016/j.jcmgh.2016.09.002
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发表时间：
2016-11
影响因子：
7.2
通讯作者：
Iwakiri Y
中科院分区：
文献类型：
--
作者：
Tanaka M;Iwakiri Y
尽管肝脏的淋巴血管系统具有维持组织液体稳态等基本功能，但对其的研究却很少。淋巴管内皮细胞特异性标记物的发现，通过影像学、细胞分离和转基因动物模型等方法推进了淋巴管的研究，并在过去十年中导致淋巴管研究取得了快速进展。这些研究提供了具体的证据，证明淋巴管功能障碍在许多疾病的发病机制中起着重要作用。本文综述了目前关于肝淋巴血管系统的结构、功能和标志物以及与肝淋巴管生成相关的因素的知识，并将肝淋巴管与其他组织中的淋巴管进行了比较。
The lymphatic vascular system has been minimally explored in the liver despite its essential functions including maintenance of tissue fluid homeostasis. The discovery of specific markers for lymphatic endothelial cells has advanced the study of lymphatics by methods including imaging, cell isolation, and transgenic animal models and has resulted in rapid progress in lymphatic vascular research during the last decade. These studies have yielded concrete evidence that lymphatic vessel dysfunction plays an important role in the pathogenesis of many diseases. This article reviews the current knowledge of the structure, function, and markers of the hepatic lymphatic vascular system as well as factors associated with hepatic lymphangiogenesis and compares liver lymphatics with those in other tissues.