Combination of 3-methyladenine therapy and Asn-Gly-Arg (NGR)-modified mesoporous silica nanoparticles loaded with temozolomide for glioma therapy in vitro.
Combination of 3-methyladenine therapy and Asn-Gly-Arg (NGR)-modified mesoporous silica nanoparticles loaded with temozolomide for glioma therapy in vitro.
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DOI：
10.1016/j.bbrc.2018.12.158
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发表时间：
2019-02
影响因子：
3.1
通讯作者：
Peng Zhang;Menghuan Tang;Qin Huang;Guanjian Zhao;Ning Huang;Xiang Zhang;Ying Tan;Yuan Cheng-
中科院分区：
文献类型：
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作者：
Peng Zhang;Menghuan Tang;Qin Huang;Guanjian Zhao;Ning Huang;Xiang Zhang;Ying Tan;Yuan Cheng-
小直径的介孔二氧化硅纳米颗粒（MSNPs）负载有抗癌药物替莫唑胺（TMZ），用聚多巴胺（PDA）包被，并与Asn-Gly-Arg（NGR）缀合用于治疗胶质瘤。NGR-MSNPs在C6细胞中的积累显示高于未修饰的MSNPs。抗癌药物可引起肿瘤细胞自噬，而自噬抑制剂可阻断这种反应，增强药物的治疗效果。在这项研究中，我们证明了MSNP-TMZ-PDA-NGR在C6细胞中具有比单独的TMZ更强的自噬和凋亡诱导作用，并且当与自噬抑制相结合时，其抗癌作用进一步增强。这些结果表明，靶向载体和自噬抑制剂的组合在胶质瘤的治疗中可能具有研究价值。
Mesoporous silica nanoparticles (MSNPs) of a small diameter were loaded with the anticancer drug temozolomide (TMZ), coated with polydopamine (PDA), and conjugated with Asn-Gly-Arg (NGR) for use in the treatment of glioma. The accumulation of NGR-MSNPs in C6 cells was shown to be higher than that of unmodified MSNPs. Anticancer drugs can cause autophagy in tumor cells, whereas autophagy inhibitors can block this reaction and enhance the therapeutic effect of the drugs. In this study, we demonstrated that MSNP-TMZ-PDA-NGR had stronger autophagy- and apoptosis-inducing effects in C6 cells than TMZ alone, and its anticancer effect was further enhanced when combined with autophagy inhibition. These results demonstrate that the combination of targeting vehicles and autophagy inhibitors may have research value in the treatment of gliomas.