Caloric restriction and experimental carcinogenesis
Caloric restriction and experimental carcinogenesis
复制标题
DOI：
10.1089/153685902317401753
复制
发表时间：
2002-04-01
期刊：
影响因子：
--
通讯作者：
Kritchevsky, D
中科院分区：
文献类型：
--
作者：
Kritchevsky, D
研究是以方法论为基础的。当我们获得了利用积累的信息的手段时，我们就取得了进步。就这样，对能量限制对癌症影响的研究经历了三个不同的时期。在Moreschi于1909年首次观察之后，这一领域的研究活跃了大约十年。然后兴趣减弱了，可能是因为考虑到当时可用的知识和方法，该领域已经走得很远了。兴趣被重新点燃，在1940年由于，主要是工作来自实验室的坦南鲍姆在迈克尔里斯医院在芝加哥和鲍曼在大学的威斯康星州。随后又进行了十年的积极研究。在此期间，我们学会了如何设计实验饮食和兴趣表达在饮食成分。到1950年，这类研究的出版物已经减少，该领域实际上休眠了30年。自20世纪80年代初以来，对这一主题的研究已经蓬勃发展，我们现在对生理学和分子生物学有足够的了解，可以探索这种现象背后的机制。能量通量，如运动，也抑制致癌作用。能量限制调节氧化性DNA损伤并增强DNA修复。现在很明显，能量限制影响肾上腺代谢，胰岛素代谢和基因表达的各个方面。了解基本机制将为控制肿瘤增殖提供重要的见解。
Research marches on the feet of methodology. Advances are made when we have acquired the means to utilize the accrued information. In this way, investigation into the influence of energy restriction in cancer has gone through three distinct periods. After the initial observation by Moreschi in 1909, there was about a decade of active research in this area. Then interest waned, possibly because the field had gone as far as it could considering the knowledge and methodology available at the time. Interest was rekindled in 1940 due, principally, to the work coming from the laboratories of Tannenbaum at the Michael Reese Hospital in Chicago and Baumann at the University of Wisconsin. Another decade of active research followed. In this period we learned how to design experimental diets and interest was expressed in dietary constituents. By 1950 publications on this type of research had dwindled and the field lay virtually dormant for 30 years. Since the early 1980s research on this topic has blossomed and we now know enough about physiology and molecular biology to probe the mechanisms underlying the phenomenon. Energy flux, as in exercise, also inhibits carcinogenesis. Energy restriction modulates oxidative DNA damage and enhances DNA repair. It is now apparent that energy restriction affects adrenal metabolism, insulin metabolism, and various aspects of gene expression. Understanding the basic mechanisms should provide important insights into control of tumor proliferation.