Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults.
Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults.
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DOI：
10.1016/j.numecd.2011.06.003
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发表时间：
2013-04
期刊：
影响因子：
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通讯作者：
Beibei Oelrich;A. Dewell;C. Gardner
中科院分区：
文献类型：
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作者：
Beibei Oelrich;A. Dewell;C. Gardner
背景和目的鱼油降低甘油三酯（TG）的作用已得到证实，但同时伴有低密度脂蛋白胆固醇（LDL-C）浓度的升高。对LDL颗粒分布的差异影响知之甚少-较小的颗粒与动脉粥样硬化的风险更大有关。我们的目的是检测血清中LDL颗粒四个亚类浓度的变化以及LDL表型模式的变化（A，B，AB）。方法和结论这是来自双盲平行设计的二次分析，安慰剂对照试验，42名成年人在12周的4 g/d EPA +治疗后经历了显著的TG降低和总LDL-C浓度的适度增加DHA。血清TG浓度降低（平均值± SEM）为−26 ± 4%（−0.81 ± 10.12 mmol/L），p < 0.0001。总LDL-C浓度增加13 ± 3%（+0.31 ± 0.08 mmol/L），p < 0.0001。LDL 1、LDL 2、LDL 3和LDL 4浓度的12周变化分别为+0.06 ± 0.02 mmol/L [+2.2 ± 0.7 mg/dL]、+0.07 ± 0.03 mmol/L [+2.6 ± 1.0 mg/dL]、+0.16 ± 0.05 mmol/L [+6.3 ± 1.8 mg/dL]，和+0.04 ± 0.04 mmol/L [+1.4 ± 1.7 mg/dL]（+20 ± 5%、+64 ± 13%、+26 ± 6%和+17 ± 9%），除LDL 4外，所有患者p < 0.05。LDL表型模式A，B和A/B的变化可以忽略不计，没有统计学意义。CONCLUSION在这一人口的hyperlipidemic成人，膳食补充鱼油导致总LDL-C浓度的增加，这是分布范围较小，更动脉粥样硬化，以及较大，更少动脉粥样硬化LDL颗粒相对均匀。
BACKGROUND AND AIMSThe well-established triglyceride (TG) lowering effect of fish oil is accompanied by an increase in LDL-cholesterol (LDL-C) concentration. Less is known about the differential impact on LDL particle distribution – the smaller particles being associated with a greater risk for atherosclerosis. We aimed to examine the changes in serum concentrations of four subclasses of LDL particles as well as shifts in LDL phenotype patterns (A, B, AB) among hypertriglyceridemic adults.METHODS AND RESULTSThis was a secondary analysis from a double-blind, parallel design, placebo controlled trial with 42 adults that experienced significant TG lowering and modest increases in total LDL-C concentrations after 12 weeks of 4 g/d EPA + DHA. Reduction in serum TG concentrations (mean ± SEM) was −26 ± 4% (−0.81 ± 10.12 mmol/L), p < 0.0001. Total LDL-C concentration increased by 13 ± 3% (+0.31 ± 0.08 mmol/L), p < 0.0001. The 12-week changes in concentrations of LDL1, LDL2, LDL3 and LDL4 were +0.06 ± 0.02 mmol/L [+2.2 ± 0.7 mg/dL], +0.07 ± 0.03 mmol/L [+2.6 ± 1.0 mg/dL], +0.16 ± 0.05 mmol/L [+6.3 ± 1.8 mg/dL], and +0.04 ± 0.04 mmol/L [+1.4 ± 1.7 mg/dL], respectively (+20 ± 5%, +64 ± 13%, +26 ± 6%, and +17 ± 9%), p < 0.05 for all but LDL4. Changes in LDL phenotype patterns A, B and A/B were negligible and not statistically significant.CONCLUSIONIn this population of hypertriglyceridemic adults, dietary supplementation with fish oil resulted in an increase in total LDL-C concentration which was distributed relatively evenly across the range of smaller and more atherogenic as well as larger and less atherogenic LDL particles.