TERMINAL PORTION OF PULMONARY ARTERIAL TREE IN PEOPLE NATIVE TO HIGH ALTITUDES
TERMINAL PORTION OF PULMONARY ARTERIAL TREE IN PEOPLE NATIVE TO HIGH ALTITUDES
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DOI：
10.1161/01.cir.28.5.915
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发表时间：
1963-01-01
期刊：
影响因子：
37.8
通讯作者：
SALDANA, M
中科院分区：
文献类型：
--
作者：
ARIASSTELLA, J;SALDANA, M
血液动力学研究表明，出生和生活在高海拔地区的人存在轻度肺动脉高压和血管阻力增加。由于肺动脉树的小肌支主要与确定血管阻力有关，因此本文对其特征进行了研究。两个系列的尸体解剖进行了调查。一个来自海拔14,300英尺的塞罗德帕斯科，另一个作为对照，来自利马的海平面。病例分为2个年龄组：1个月~ 2岁和6 ~ 76岁。在两个系列中考虑了年龄大致匹配的受试者。在高海拔系列中，发现了所有年龄段的外周肺动脉分支的更广泛的肌化：成人近端肺动脉的真正肥大;以及在年轻年龄段的远端动脉中发生某种程度的血管收缩的证据。可能引起这些变化的因素进行了讨论。这一结果为进一步认识高原肺动脉高压的发生提供了解剖学基础。
Hemodynamic studies have disclosed that people born and living at high altitudes present a mild degree of pulmonary arterial hypertension and increased vascular resistance. Since the small muscular branches of the pulmonary arterial tree are primarily concerned in determining vascular resistance a study of their characteristics is here presented. Two series of autopsies were investigated. One from Cerro de Pasco at 14,300 feet above sea level, and the other, used as control, from Lima at sea level. Cases were arranged in 2 age groups: from 1 month to 2 years and from 6 to 76 years. Subjects of approximately matching ages were considered in both series. A more extensive muscularization of the peripheral pulmonary arterial branches at all ages: true hypertrophy of the proximal pulmonary arteries in adults; and evidence that some degree of vasocon-striction occur in the distal arteries in younger ages, were found in the high altitude series. The factors which probably give rise to these changes are discussed. It is believed that the results give an anatomical basis for understanding the genesis of high altitude pulmonary hypertension.