Oxytocin neurone autoexcitation during morphine withdrawal in anaesthetized rats
Oxytocin neurone autoexcitation during morphine withdrawal in anaesthetized rats
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DOI：
10.1097/00001756-199703030-00027
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发表时间：
1997-03-03
期刊：
影响因子：
1.7
通讯作者：
Russell, JA
中科院分区：
文献类型：
--
作者：
Brown, CH;Munro, G;Russell, JA
我们调查是否催产素释放到视上核参与吗啡戒断兴奋催产素神经元。吗啡依赖大鼠视上核的纳洛酮后透析使核内催产素释放增加56.5p +/-12.7%，而在溶剂处理的依赖大鼠中没有观察到变化。在另一项实验中，在吗啡依赖大鼠中，静脉内（i. v.）纳洛酮，脑室内（i. c. v.）与i. c. v.载体（62倍增加）相比，催产素受体拮抗剂注射降低了血浆催产素浓度的增加（至28倍）。最后，在静脉注射催产素拮抗剂的情况下，吗啡戒断后催产素神经元放电频率的增加为稳态放电频率的28%（15-20分钟后），这一增加低于稳态放电频率（P
WE investigated whether release of oxytocin into the supraoptic nucleus is involved in morphine-withdrawal excitation of oxytocin neurones. Retrodialysis of naloxone into the supraoptic nucleus of morphine-dependent rats increased intranuclear oxytocin release by 56.5p +/-12.7% whereas no change was seen in vehicle-treated dependent rats. In another experiment, in morphine-dependent rats given intravenous (i.v.) naloxone, intracerebroventricular (i.c.v.) oxytocin receptor antagonist injection reduced the increase of plasma oxytocin concentration (to 28-fold) compared with i.c.v. vehicle (62-fold increase). Finally, the increase in oxytocin neurone firing rate following morphine-withdrawal in the presence of i.c.v. oxytocin antagonist infusion was 28% of the steady state firing rate (15-20 min later) and this was lower (p