Quantitation of changes in the content of neurohypophyseal peptides in hypothalamic nuclei after adrenalectomy.
Quantitation of changes in the content of neurohypophyseal peptides in hypothalamic nuclei after adrenalectomy.
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肾上腺切除术后下丘脑核中神经垂体肽含量变化的定量。
DOI：
10.1159/000123479
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发表时间：
1983
影响因子：
4.1
通讯作者：
Brownstein,MJ
中科院分区：
文献类型：
--
作者：
Robinson,AG;Seif,SM;Verbalis,JG;Brownstein,MJ
在肾上腺功能不全的情况下，通过免疫组织学测定，正中隆起的外部区域中加压素的含量增加。我们研究了双侧肾上腺切除术后的大鼠，并获得了视上核、室旁核和视交叉上核以及正中隆起和垂体后叶的穿孔样本。垂体后叶中加压素、神经素和催产素的含量均减少，但视交叉上核和正中隆起的加压素含量显着增加。正中隆起中加压素水平的增加被解释为轴突中含量的代表，并证明加压素转运的大量增加。在 SON 和 PVN 中，在增强合成和运输的状态下，加压素的含量没有增加，表明加压素从合成位点快速移动到运输系统中。视交叉上核中加压素含量的增加表明，该水平的加压素也随着肾上腺功能的变化而变化。整个神经垂体中催产素的水平并未与加压素同时变化，这表明神经垂体激素的反应具有相对选择性。
In adrenal insufficiency there is an increase in the content of vasopressin in the external zone of the median eminence as determined by immunohistology. We studied rats after bilateral adrenalectomy and obtained punched samples of the supraoptic, the paraventricular, and the suprachiasmatic nuclei, and from the median eminence and the posterior pituitary. Vasopressin, neurophysin and oxytocin were all decreased in content in the posterior pituitary but in the suprachiasmatic nucleus and in the median eminence there was a significant increase in the content of vasopressin. The increased levels of vasopressin in the median eminence are interpreted as representative of the content in axons and demonstrate a large increase of transport of vasopressin. In the SON and PVN there was no increase in the content of vasopressin during this state of augmented synthesis and transport, indicating that vasopressin moves rapidly from the site of synthesis into the transport system. The increased content of vasopressin in the suprachiasmatic nucleus shows that vasopressin at this level also varies with changes in adrenal function. Levels of oxytocin throughout the neurohypophysis did not change in parallel with vasopressin demonstrating relatively selective responses of the neurohypophyseal hormones.