Risk factors for intrahepatic and extrahepatic Cholangiocarcinoma in the United States: A population-based case-control study
Risk factors for intrahepatic and extrahepatic Cholangiocarcinoma in the United States: A population-based case-control study
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DOI：
10.1016/j.cgh.2007.05.020
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发表时间：
2007-10-01
影响因子：
12.6
通讯作者：
McGlynn, Katherine A.
中科院分区：
文献类型：
--
作者：
Welzelt, Tania M.;Graubard, Barry I.;McGlynn, Katherine A.
背景与目的：肝内和肝外胆管癌是胆管中罕见的高度恶性肿瘤。尽管肝外胆管癌（ECC）的发病率保持不变，但肝内胆管癌（ICC）的发病率在美国有所增加。由于这两种肿瘤的病因尚不清楚，因此进行了一项基于人群的病例对照研究，以检查ECC和ICC与先前存在的医疗状况的关系。方法：535例ICC患者、549例ECC患者（1993-1999年诊断）和102,782例无癌对照者的医疗状况通过监测、流行病学和最终结果-医疗保险数据库进行鉴定。采用Logistic回归分析计算调整后的优势比。结果：除了已知的危险因素（胆总管囊肿、胆管炎、炎症性肠病）外，其他几种情况与ECC和ICC显著相关：胆汁性肝硬化(ECC, ICC: P
Background & Aims: Intrahepatic and extrahepatic cholangiocarcinomas are rare and highly malignant cancers of the bile duct. Although the incidence of extrahepatic cholangiocarcinoma (ECC) has remained constant, the incidence of intrahepatic cholangiocarcinoma (ICC) has increased in the United States. Because the etiology of both tumors is poorly understood, a population-based case-control study was conducted to examine the association of ECC and ICC with preexisting medical conditions. Methods: Medical conditions among 535 ICC patients, 549 ECC patients (diagnosed 1993-1999), and 102,782 cancer-free controls were identified by using the Surveillance, Epidemiology and End Results-Medicare databases. Logistic regression analysis was used to calculate adjusted odds ratios. Results: In addition to established risk factors (choledochal cysts, cholangitis, inflammatory bowel disease), several other conditions were significantly associated with ECC and ICC: biliary cirrhosis (ECC, ICC: P