The global burden of listeriosis: a systematic review and meta-analysis.
The global burden of listeriosis: a systematic review and meta-analysis.
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DOI：
10.1016/s1473-3099(14)70870-9
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发表时间：
2014-11
影响因子：
56.3
通讯作者：
Speybroeck, Niko
中科院分区：
文献类型：
--
作者：
de Noordhout, Charline Maertens;Devleesschauwer, Brecht;Angulo, Frederick J.;Verbeke, Geert;Haagsma, Juanita;Kirk, Martyn;Havelaar, Arie;Speybroeck, Niko
由单核细胞增生李斯特菌引起的李斯特菌病是一种重要的食源性疾病，难以控制，通常会导致严重的临床后果。我们的目标是通过系统性综述综合信息和知识，提供全球疾病、死亡和残疾调整生命年（DADs）的初步估计。我们通过对同行评议和灰色文献（1990-2012年发表）的系统性综述检索了关于绦虫病的数据。我们从分析中排除了1990年以前的发病率数据。我们审查了现有的国家监测数据。我们进行了一项多水平荟萃分析，以填补缺失的国家特异性梅毒发病率。我们使用了元回归来计算健康状态的比例，并使用蒙特卡罗模拟来生成WHO分区域的DADs。我们筛选了11722篇参考文献，并确定了87项包含绦虫病数据的合格研究纳入荟萃分析。我们估计，在2010年，登革热导致23150例疾病（95%可信区间6061- 91247），5463例死亡（1401- 21497）和172823例死亡（44079 - 676465）。围产期病例占20.7%（SD 1.7）。我们对结核病全球负担的量化将使国际优先考虑工作成为可能。先天性弓形虫病与包虫病相比，前者发病率较低，而后者发病率较高。迫切需要努力填补发展中国家的缺失数据。我们无法确定AFRO、EMRO和SEARO WHO区域的发病率数据。世卫组织食源性疾病流行病学咨商小组和鲁汶天主教大学。
Listeriosis, caused by Listeria monocytogenes, is an important foodborne disease that can be difficult to control and commonly results in severe clinical outcomes. We aimed to provide the first estimates of global numbers of illnesses, deaths, and disability-adjusted life-years (DALYs) due to listeriosis, by synthesising information and knowledge through a systematic review. We retrieved data on listeriosis through a systematic review of peer-reviewed and grey literature (published in 1990–2012). We excluded incidence data from before 1990 from the analysis. We reviewed national surveillance data where available. We did a multilevel meta-analysis to impute missing country-specific listeriosis incidence rates. We used a meta-regression to calculate the proportions of health states, and a Monte Carlo simulation to generate DALYs by WHO subregion. We screened 11 722 references and identified 87 eligible studies containing listeriosis data for inclusion in the meta-analyses. We estimated that, in 2010, listeriosis resulted in 23 150 illnesses (95% credible interval 6061–91 247), 5463 deaths (1401–21 497), and 172 823 DALYs (44 079–676 465). The proportion of perinatal cases was 20·7% (SD 1·7). Our quantification of the global burden of listeriosis will enable international prioritisation exercises. The number of DALYs due to listeriosis was lower than those due to congenital toxoplasmosis but accords with those due to echinococcosis. Urgent efforts are needed to fill the missing data in developing countries. We were unable to identify incidence data for the AFRO, EMRO, and SEARO WHO regions. WHO Foodborne Diseases Epidemiology Reference Group and the Université catholique de Louvain.