A decade of e-cigarettes: Limited research & unresolved safety concerns.
A decade of e-cigarettes: Limited research & unresolved safety concerns.
复制标题
DOI：
10.1016/j.tox.2016.07.020
复制
发表时间：
2016-07-15
期刊：
影响因子：
4.5
通讯作者：
Cucullo L
中科院分区：
文献类型：
--
作者：
Kaisar MA;Prasad S;Liles T;Cucullo L
众所周知，烟草消费是全世界可预防死亡的主要原因，并且与癌症、慢性阻塞性肺病、动脉粥样硬化、中风和许多神经/神经退行性疾病等主要疾病有关。在过去的十年中，许多替代电子烟产品进入市场，迅速赢得了消费者，尤其是年轻人的青睐。电子尼古丁输送系统或电子烟已成为抢手的产品，因为人们相信它们比传统香烟安全得多。然而，电子烟的制造工艺和电子烟溶液的内容研究不足且缺乏监管指南已成为主要问题。电子烟是否可以帮助吸烟者戒烟以及电子烟是否会促进非吸烟者使用尼古丁等备受争议和悬而未决的问题加剧了人们对电子烟安全性的困惑。在这篇评论文章中，我们总结了目前对电子烟潜在健康影响的理解（和缺乏）。我们还将重点介绍最新的研究（体内/体外），这些研究似乎与制造商提出的广泛安全声明相冲突。最后，我们提供了潜在的解决方案，以克服电子烟短期和长期健康影响的研究空白。
It is well known that tobacco consumption is a leading cause of preventable deaths worldwide and has been linked to major diseases ranging from cancer to chronic obstructive pulmonary disease, atherosclerosis, stroke and a host of neurological/neurodegenerative disorders. In the past decade a number of alternative vaping products have hit the market, rapidly gaining consumers especially among the younger population. Electronic nicotine delivery systems or e-cigarettes have become the sought-after product due to the belief that they are much safer than traditional cigarettes. However, inadequate research and lack of regulatory guidelines for both the manufacturing process and the content of the vaping solution of the e-cigarette has become a major concern. Highly debated and unresolved questions such as whether e-cigarettes may help smokers quit and whether e-cigarettes will promote the use of nicotine among non-smokers add to the confusion of the safety of e-cigarettes. In this review article, we summarize the current understanding (and lack thereof) of the potential health impacts of e-cigarettes. We will also highlight the most recent studies (in vivo/in vitro) which seem to conflict with the broad safety claims put forward by the manufacturers. Finally, we provide potential solutions to overcome the research gap of the short and long-term health impact of e-cigarettes.