Determinants of tissue delivery for 129Xe magnetic resonance in humans
Determinants of tissue delivery for 129Xe magnetic resonance in humans
复制标题
人体 129Xe 磁共振组织输送的决定因素
DOI：
--
复制
发表时间：
1996
影响因子：
3.3
通讯作者：
R. Walsworth
中科院分区：
文献类型：
--
作者：
S. Peled;F. Jolesz;C. Tseng;L. Nascimben;M. Albert;R. Walsworth
使用激光偏振129的磁共振成像是一种新技术，首先由Albert等人（Nature 370，1994）证明，他们获得了切除小鼠肺的129图像。本文介绍了影响吸入极化129氚在人体组织中蓄积的因素。由此产生的模型预测的129欧姆磁化在不同的组织作为一个函数的时间从吸入开始，组织灌注率和分配系数氙，和相关的T1衰减时间。129氘在生物组织中的弛豫时间目前还不清楚。用这些参数的估计值替代，得到的脑中极化129 MRS MR的预期信噪比（SNR）约为质子MR等效SNR的2%。
Magnetic resonance imaging using laser‐polarized 129Xe is a new technique first demonstrated by Albert et al. (Nature 370, 1994) who obtained a 129Xe image of an excised mouse lung. This paper describes the factors influencing the accumulation of inhaled, polarized 129Xe in human tissue. The resulting model predicts the 129Xe magnetization in different tissues as a function of the time from the start of inhalation, the tissue perfusion rate and partition coefficient for xenon, and the relevant T1 decay times. The relaxation times of 129Xe in biological tissues are not yet known precisely. Substitution of estimated values for these parameters results in an expected signal‐to‐noise ratio (SNR) from polarized 129Xe MR in the brain of approximately 2% of the equivalent SNR from proton MR.