Chronic peripheral nerve compression disrupts paranodal axoglial junctions.
Chronic peripheral nerve compression disrupts paranodal axoglial junctions.
复制标题
慢性周围神经受压会破坏节旁轴胶质连接。
DOI：
10.1002/mus.25273
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发表时间：
2017
期刊：
影响因子：
3.4
通讯作者：
Susuki,Keiichiro
中科院分区：
文献类型：
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作者：
Otani,Yoshinori;Yermakov,LeonidM;Dupree,JeffreyL;Susuki,Keiichiro
周围神经经常暴露于机械应力，导致压迫性神经病。慢性compression.MethodsWe神经功能障碍的病理生理学基础是在很大程度上unknown.我们分析了分子组织和精细结构的Ranvier节点和附近的压缩神经病模型中，其中一个硅橡胶管被放置在小鼠坐骨神经周围。ResultsImmunofluorescence研究表明，集群的细胞粘附复合物形成paranodal axoglial junctions是分散和重叠频繁与aprotaparanodal组件。这些结旁改变发生时没有结间髓鞘损伤。结旁破坏的分布和模式表明，这些变化是机械应力的直接结果。电子显微镜证实损失paranodal axoglial junctions.ConclusionsOur数据表明，慢性神经压迫破坏paranodal交界处和轴突域所需的适当的周围神经功能。这些结果为更好地理解压迫性神经病中神经功能障碍的病理生理学提供了重要线索。肌肉神经55：544-554，2017
IntroductionPeripheral nerves are often exposed to mechanical stress leading to compression neuropathies. The pathophysiology underlying nerve dysfunction by chronic compression is largely unknown.MethodsWe analyzed molecular organization and fine structures at and near nodes of Ranvier in a compression neuropathy model in which a silastic tube was placed around the mouse sciatic nerve.ResultsImmunofluorescence study showed that clusters of cell adhesion complex forming paranodal axoglial junctions were dispersed and overlapped frequently with juxtaparanodal components. These paranodal changes occurred without internodal myelin damage. The distribution and pattern of paranodal disruption suggests that these changes are the direct result of mechanical stress. Electron microscopy confirmed loss of paranodal axoglial junctions.ConclusionsOur data show that chronic nerve compression disrupts paranodal junctions and axonal domains required for proper peripheral nerve function. These results provide important clues toward better understanding of the pathophysiology underlying nerve dysfunction in compression neuropathies.Muscle Nerve55: 544–554, 2017
Hirayama Y、Matsunaga T 等人：“粒细胞集落刺激因子增强同种异体外周血干细胞移植供者 CD4 阳性外周血淋巴细胞中转化生长因子-β mRNA 的表达”Am
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DOI：
10.1053/j.ajkd.2016.01.030
发表时间：
2016-07
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
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作者：
Francis JM;Beck LH Jr;Salant DJ
通讯作者：
Salant DJ
影响因子：
3.4
作者：
Hashimoto, Yu;Ogata, Hidenori;Kira, Jun-ichi
通讯作者：
Kira, Jun-ichi