Interleukin-37 mediates the antitumor activity in hepatocellular carcinoma: role for CD57+ NK cells.
Interleukin-37 mediates the antitumor activity in hepatocellular carcinoma: role for CD57+ NK cells.
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Interleukin-37 介导肝细胞癌中的抗肿瘤活性：CD57 NK 细胞的作用。
DOI：
10.1038/srep05177
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发表时间：
2014-06-05
影响因子：
4.6
通讯作者：
Xia JC
中科院分区：
文献类型：
--
作者：
Zhao JJ;Pan QZ;Pan K;Weng DS;Wang QJ;Li JJ;Lv L;Wang DD;Zheng HX;Jiang SS;Zhang XF;Xia JC
白细胞介素-37（IL-37）在癌症中的生物学作用尚不清楚。通过对163例原发性肝细胞癌（HCC）临床标本进行免疫组化检测，发现肿瘤组织中IL-37表达降低，且表达水平与肿瘤大小呈负相关。IL-37在HCC肿瘤组织中的高表达与较好的总生存期（OS）和无病生存期（DFS）相关。肿瘤组织中IL-37表达与肿瘤浸润的CD 57+自然杀伤（NK）细胞密度呈正相关，但与CD 3+和CD 8 + T细胞无关。体外趋化性分析表明，IL-37过表达的肝癌细胞可以募集更多的NK细胞。体内小鼠模型实验还显示，在HCC细胞中过表达IL-37显著延迟肿瘤生长并将更多的NK细胞募集到肿瘤组织中。提示IL-37可能通过调节先天免疫功能对肝癌患者的预后起重要作用。
The biological role of interleukin-37 (IL-37) in cancer is large unknown. Through immunohistochemical detection using 163 primary hepatocellular carcinoma (HCC) clinical specimens, we found the expression of IL-37 was decreased in tumor tissues, and the expression level was negatively correlated with tumor size. High expression of IL-37 in HCC tumor tissues was associated with better overall survival (OS) and disease-free survival (DFS). IL-37 expression in tumor tissues was positively associated with the density of tumor-infiltrating CD57+ natural killer (NK) cells, but not with the CD3+ and CD8+ T cells. Consistently, in vitro chemotaxis analysis showed that IL-37- overexpressing HCC cells could recruit more NK cells. The in vivo mouse model experiments also revealed that overexpression IL-37 in HCC cells significantly delayed tumor growth and recruited more NK cells into tumors tissues. Our finding suggested that IL-37 might play an important role for the prognosis of HCC patients via regulating innate immune-action.
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影响因子：
7.3
作者：
Moretta L;Pietra G;Montaldo E;Vacca P;Pende D;Falco M;Del Zotto G;Locatelli F;Moretta A;Mingari MC
通讯作者：
Mingari MC
影响因子：
6.4
作者：
Nakagawa, Hayato;Maeda, Shin;Omata, Masao
通讯作者：
Omata, Masao
影响因子：
3.9
作者：
Schroten, Caroline;Scheffer, Reinilde;Kraaij, Robert
通讯作者：
Kraaij, Robert
影响因子：
7.2
作者：
Senovilla L;Vacchelli E;Galon J;Adjemian S;Eggermont A;Fridman WH;Sautès-Fridman C;Ma Y;Tartour E;Zitvogel L;Kroemer G;Galluzzi L
通讯作者：
Galluzzi L
影响因子：
13.5
作者：
Jiang, Runqiu;Tan, Zhongming;Sun, Beicheng
通讯作者：
Sun, Beicheng