MOLECULAR-BIOLOGY OF LEARNING - MODULATION OF TRANSMITTER RELEASE
MOLECULAR-BIOLOGY OF LEARNING - MODULATION OF TRANSMITTER RELEASE
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DOI：
10.1126/science.6289442
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
SCHWARTZ, JH
中科院分区：
文献类型：
--
作者：
KANDEL, ER;SCHWARTZ, JH
直到最近，用细胞生物学的技术来学习还不可能。在过去的几年里，人们对高等无脊椎动物的基本学习形式进行了分析。他们的神经系统允许实验研究行为、神经生理、形态、生化和遗传成分的功能（可塑性）变化的基础学习。在这篇综述中，我们主要集中在海洋软体动物鳃和虹吸反射的短期敏化。对这种学习形式的分析提供了直接证据，证明依赖于单磷酸环腺苷的蛋白质磷酸化可以调节突触的作用。这些研究还表明，这种短期形式的突触可塑性的分子机制可以扩展到解释长期记忆和经典条件反射。
Until recently, it has been impossible to approach learning with the techniques of cell biology. During the past several years, elementary forms of learning have been analyzed in higher invertebrates. Their nervous systems allow the experimental study of behavioral, neurophysiological, morphological, biochemical, and genetic components of the functional (plastic) changes underlying learning. In this review, we focus primarily on short-term sensitization of the gill and siphon reflex in the marine mollusk,Aplysia californica. Analyses of this form of learning provide direct evidence that protein phosphorylation dependent on cyclic adenosine monophosphate can modulate synaptic action. These studies also suggest how the molecular mechanisms for this short-term form of synaptic plasticity can be extended to explain both long-term memory and classical conditioning.