Estimation of glomerular filtration rate and technetium-99m diethylene triamine penta-acetic acid using chromium-51 ethylene diamine tetra-acetic acid
Estimation of glomerular filtration rate and technetium-99m diethylene triamine penta-acetic acid using chromium-51 ethylene diamine tetra-acetic acid
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使用铬 51 乙二胺四乙酸估算肾小球滤过率和锝99m二亚乙基三胺五乙酸
DOI：
10.1007/bf00817277
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
G. Camuzzini
中科院分区：
文献类型：
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作者：
A. Biggi;A. Viglietti;M. C. Farinelli;C. Bonada;G. Camuzzini
同时测定了54例功能范围为9 ~ 176 ml/min的患者对铬-51乙二胺四乙酸（51Cr-EDTA）和锝-99m二乙烯三胺五乙酸（99mTc-DTPA）的清除率。两种清除率相关性较好（r = 0.97, SEE 8.6 ml/min）， DTPA清除率高出2.9%。对于每种放射性药物，将使用多个血液样本获得的血浆清除率与简化方法（即60-180分钟的Russell双样本法和带Brochner-Mortensen校正的单指数法）进行比较。两种放射性药物的清除率均与罗素法（r = 0.99， EDTA为SEE 4.1 ml/min;r = 0.99， DTPA为SEE 4.9 ml/min）和单指数法（r = 0.99， EDTA为SEE 3.6 ml/min;r = 0.99， DTPA为SEE 3.9 ml/min）相关良好。在肾小球滤过率(GFR)<30 ml/min或GFR≥30 ml/min的患者中，使用多个血液样本获得的平均血浆清除率与Russell方法获得的平均血浆清除率没有显著差异。由于在GFR≥30 ml/min的患者中观察到的差异很大，使用多个血液样本获得的平均血浆清除率与单指数法获得的平均血浆清除率有显著差异。结论99mtc - dtpa注射后罗素双样品法准确，可用于临床常规应用。
Simultaneous measurements of the clearance rate of chromium-51 ethylene diamine tetra-acetic acid (51Cr-EDTA) and technetium-99m diethylene triamine penta-acetic acid (99mTc-DTPA) were performed in 54 patients with a range of function between 9 and 176 ml/min. Using multiple blood samples the two clearance values correlated well (r = 0.97, SEE 8.6 ml/min) and DTPA clearance was higher by 2.9%. For each radiopharmaceutical the plasma clearance rates obtained using multiple blood samples were compared with those obtained with simplified methods, i.e., the 60–180 min two-sample method of Russell and the mono-exponential method with the Brochner-Mortensen correction. For both radiopharmaceuticals the clearance values correlated well with the Russell method (r = 0.99, SEE = 4.1 ml/min for EDTA;r = 0.99, SEE 4.9 ml/min for DTPA) and the mono-exponential method (r = 0.99, SEE 3.6 ml/min for EDTA;r = 0.99, SEE 3.9 ml/min for DTPA). The mean plasma clearance obtained using multiple blood samples did not differ significantly from that obtained with the Russell method, either in patients with a glomerular filtration rate (GFR)<30 ml/min or in patients with GFR≥30 ml/min. The mean plasma clearance obtained using multiple blood samples differed significantly from that obtained with the mono-exponential method because of the great difference observed in patients with GFR≥30 ml/min. It is concluded that the Russell two-sample method after injection of99mTc-DTPA is accurate enough for routine clinical use.