Monitoring the efficacy of plaque control methods.
Monitoring the efficacy of plaque control methods.
复制标题
监测菌斑控制方法的有效性。
DOI：
10.1111/j.1600-0757.1995.tb00043.x
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Scannapieco,FA
中科院分区：
文献类型：
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作者：
Scannapieco,FA
为了在临床试验中正确评估治疗方式或药物，必须明确定义逻辑，客观的终点并易于测试。在医学上，评估的终点通常是特定疾病发病率的降低。不幸的是，在龋齿和牙周炎等牙科疾病的情况下，这些终点很难监测，主要是因为这些口腔疾病通常需要很长的病程。因此，在足够长的时间内进行临床试验以评估干预措施对口腔疾病发病率的影响通常是不切实际的。另一方面，由于已知这些口腔疾病是牙菌斑作用的结果，因此监测牙菌斑形成和发展的各个方面以确定特定治疗方法或药剂的潜在临床功效是合理的。本章简要回顾了牙菌斑和特定微生物在龋病和牙周炎病因学中的作用，并描述和评价了各种方法，可用于监测牙菌斑和牙菌斑微生物随着时间的推移。这些方法在监测斑块控制方法的疗效的有用性进行了讨论的背景下，非特异性或特异性斑块假说。
In order for a treatment modality or pharmaceutical agent to be properly evaluated in a clinical trial, a logical, objective endpoint must be clearly defined and easily tested. In medicine, the endpoint evaluated is often a reduction in the incidence of a specific disease. Unfortunately, in the case of dental diseases such as caries and periodontitis, such endpoints are difficult to monitor primarily because these oral diseases often take a prolonged course. Thus, it is often impractical to conduct clinical trials over a sufficiently long period of time to assess the effects of an intervention on the incidence of oral disease. On the other hand, since these oral diseases are known to be the result of the action of dental plaque, it is reasonable to monitor aspects of plaque formation and development to determine the potential clinical efficacy of a specific therapeutic method or agent. This chapter briefly reviews the role of plaque and specific microorganisms in the etiology of caries and periodontitis and describes and evaluates critically the various methods available to monitor plaque and plaque microorganisms over time. The usefulness of these methods in monitoring the efficacy of plaque control methods is discussed in the context of the nonspecific or specific plaque hypotheses.