Hereditary disorders among Iranian Jews.
Hereditary disorders among Iranian Jews.
复制标题
伊朗犹太人的遗传性疾病。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
J. Zlotogora
中科院分区：
文献类型：
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作者：
J. Zlotogora
伊朗犹太人代表着一个具有高度近亲繁殖的古老社区。虽然该社区仍然相对孤立，但它与伊拉克的巴比伦犹太人有着密切的联系。据报道，伊朗犹太人中经常发生几种遗传性疾病，特别是皮质酮甲氧合酶缺乏症II型，多腺综合征和边缘空泡肌病。根据我们诊所收集的数据，隐性和显性耳聋似乎也很常见。其他疾病，如β-地中海贫血、色盲、缺损性小眼症、Dubin-Johnson综合征和先天性重症肌无力，在伊朗和伊拉克犹太社区都很常见。这些家庭在伊朗境内的原籍地和分子研究的结果表明，伊朗犹太人中这些疾病的发生率很高是有原因的。虽然高频率的一些疾病，如皮质酮甲基氧化酶缺乏症II型，代表了创始人的影响，在其他疾病（如β地中海贫血），它是次要的杂合子优势。
Iranian Jews represent an ancient community with a very high degree of inbreeding. Although the community remained relatively isolated, it had strong ties with Babylonian Jewry in Iraq. Several genetic disorders have been reported to be frequent among Iranian Jews, in particular, corticosterone methyloxydase deficiency type II, polyglandular syndrome, and rimmed vacuole myopathy. Based on the data collected in our clinic, recessive and dominant deafness also appear to be frequent. Other diseases, such as beta-thalassemia, achromatopsia, colobomatous microphthalmia, Dubin-Johnson syndrome, and congenital myasthenia gravis, were frequent in both the Iranian and Iraqi Jewish communities. The place of origin of the families within Iran and the results of molecular studies suggest some reason(s) for the high frequency of these disorders among Iranian Jews. While the high frequency of some of the disorders, such as corticosterone methyloxydase deficiency type II, represents a founder effect, in other diseases (such as beta-thalassemia) it was secondary to heterozygote advantage.
DOI：
10.1073/pnas.86.20.8083
发表时间：
1989-10-01
影响因子：
11.1
作者：
GODOWSKI, PJ;LEUNG, DW;WOOD, WI
通讯作者：
WOOD, WI
DOI：
10.1073/pnas.89.11.4996
发表时间：
1992-06-01
影响因子：
11.1
作者：
PASCOE, L;CURNOW, KM;WHITE, PC
通讯作者：
WHITE, PC