Active gel model of amoeboid cell motility
Active gel model of amoeboid cell motility
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DOI：
10.1088/1367-2630/15/2/025022
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发表时间：
2013-02-18
影响因子：
3.3
通讯作者：
Voituriez, R.
中科院分区：
文献类型：
--
作者：
Callan-Jones, A. C.;Voituriez, R.
我们在活性凝胶理论的基础上建立了一个阿米巴细胞运动模型。将真核细胞的运动装置模拟为有限长度的孔弹性活性凝胶被溶剂渗透的受限层，我们首先证明，由于活应力和凝胶的更替，最初的静态和均匀的层可以经历收缩类型的不稳定性到极化的运动状态，在该状态下后面富含凝胶聚合物。这与运动细胞在其后部含有富含肌动球蛋白的尾足类动物是定性一致的。我们发现，凝胶层在很长一段时间内处于稳定移动的不均匀状态，维持在收缩和细丝周转之间的平衡。此外，我们的模型预测了导致最大层速度的凝胶-底物粘附力的最佳值，这与细胞运动分析相一致。该模型可能与细胞在复杂、受限的环境中移动的运动性有关，这种环境可以通过细胞通过微通道的迁移来实验模拟。
We develop a model of amoeboid cell motility based on active gel theory. Modeling the motile apparatus of a eukaryotic cell as a confined layer of finite length of poroelastic active gel permeated by a solvent, we first show that, due to active stress and gel turnover, an initially static and homogeneous layer can undergo a contractile-type instability to a polarized moving state in which the rear is enriched in gel polymer. This agrees qualitatively with motile cells containing an actomyosin-rich uropod at their rear. We find that the gel layer settles into a steadily moving, inhomogeneous state at long times, sustained by a balance between contractility and filament turnover. In addition, our model predicts an optimal value of the gel-substrate adhesion leading to maximum layer speed, in agreement with cell motility assays. The model may be relevant to motility of cells translocating in complex, confining environments that can be mimicked experimentally by cell migration through microchannels.