A behavioral method to estimate charge integration efficiency in cochlear implant users.
A behavioral method to estimate charge integration efficiency in cochlear implant users.
复制标题
一种估计人工耳蜗用户电荷积分效率的行为方法。
DOI：
10.1016/j.jneumeth.2020.108802
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发表时间：
2020
影响因子：
3
通讯作者：
Galvin3rd,JohnJ
中科院分区：
文献类型：
--
作者：
Zhou,Ning;Dong,Lixue;Galvin3rd,JohnJ
在人工耳蜗中，脉冲振幅（PA）或脉冲相位持续时间（PPD）可以用来增加响度。随着PPD的增加，响度增长更慢，导致更大的动态范围（DR），可能反映了与听力损失引起的神经变性相关的“泄漏”电荷整合。在此，我们提出了一种估算CI用户电荷集成效率的方法。新方法相对于较短PPD （25μs/ph）的普通阈值锚，通过增加PA或PPD来测量DR；DRs被转换为普通电荷单位（nC）。电荷积分效率计算为DR随PPD或PA增加的dB差。当PA或PPD相对于共同阈值增加时，也比较了响度增长函数。结果检测了10只CI耳；所有参与者均为Cochlear©设备的成年使用者。当PPD增加时，DR明显增大，比PA增加时（平均）需要多70%的电荷。耳聋持续时间与电荷整合效率之间存在显著相关性（p = 0.007），这在很大程度上是由双耳长期听觉剥夺的参与者造成的。当PPD增加时，响度增长变慢，与先前的研究一致。与现有方法的比较。本方法提供了一种快速的行为测试方法来测量电荷整合效率，这可能是一种有用的神经健康指标。电荷整合效率可以用来探测神经健康独立于绝对检测阈值，这主要反映电极接近神经群。
BackgroundIn cochlear implants, pulse amplitude (PA) or pulse phase duration (PPD) can be used to increase loudness. Loudness grows more slowly with increasing PPD, resulting in a larger dynamic range (DR), possibly reflecting “leaky” charge integration associated with neural degeneration due to hearing loss. Here, we propose a method to estimate charge integration efficiency for CI users.New methodThe DR was measured with increasing PA or PPD, relative to a common threshold anchor with a short PPD (25μs/ph); DRs were converted to the common unit of charge (nC). Charge integration efficiency was calculated as the dB difference in DR with increasing PPD or PA. Loudness growth functions were also compared as PA or PPD was increased relative to the common threshold.ResultsTen CI ears were tested; all participants were adult users of Cochlear© devices. DR was significantly larger when PPD was increased, requiring (on average) 70 % more charge than when PA was increased. A significant correlation (p = 0.007) was observed between duration of deafness and charge integration efficiency, largely driven by a participant with long auditory deprivation in both ears. Loudness growth was slower when PPD was increased, consistent with previous studies.Comparison to Existing Methods. The present method offers a quick behavioral test with which to measure charge integration efficiency, which may be a useful measure of neural health.DiscussionCharge integration efficiency may be used to probe neural health independent of absolute detection thresholds, which mostly reflect the proximity of electrodes to neural populations.