Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors.
Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors.
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DOI：
10.3389/fnmol.2015.00060
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发表时间：
2015
影响因子：
4.8
通讯作者：
Patrick GN
中科院分区：
文献类型：
--
作者：
Goo MS;Scudder SL;Patrick GN
突触强度的变化是学习和记忆的基础，部分受兴奋性突触突触后膜AMPA型谷氨酸受体的插入或去除控制。一旦内化，这些受体可以通过与其他蛋白质的亚基特异性相互作用或通过翻译后修饰如磷酸化再循环回到质膜。或者，这些受体可以被靶向通过细胞中的多种降解途径破坏。泛素化是另一种翻译后修饰，最近成为调节谷氨酸受体再循环和运输的关键信号。在这篇综述中，我们将讨论泛素化在离子型谷氨酸受体的运输和周转以及兴奋性突触可塑性中的作用。
Changes in synaptic strength underlie the basis of learning and memory and are controlled, in part, by the insertion or removal of AMPA-type glutamate receptors at the postsynaptic membrane of excitatory synapses. Once internalized, these receptors may be recycled back to the plasma membrane by subunit-specific interactions with other proteins or by post-translational modifications such as phosphorylation. Alternatively, these receptors may be targeted for destruction by multiple degradation pathways in the cell. Ubiquitination, another post-translational modification, has recently emerged as a key signal that regulates the recycling and trafficking of glutamate receptors. In this review, we will discuss recent findings on the role of ubiquitination in the trafficking and turnover of ionotropic glutamate receptors and plasticity of excitatory synapses.