Instrumental learning within the spinal cord II. Evidence for central mediation
Instrumental learning within the spinal cord II. Evidence for central mediation
复制标题
DOI：
10.1016/s0031-9384(02)00859-4
复制
发表时间：
2002-11-01
影响因子：
2.9
通讯作者：
Grau, JW
中科院分区：
文献类型：
--
作者：
Crown, ED;Ferguson, AR;Grau, JW
在第二胸椎处脊髓横断的大鼠如果接受腿部电击以伸展肢体，则可以学会将其腿保持在屈曲位置。这些大鼠表现出屈曲反应持续时间的增加，使净冲击暴露最小化。目前的一组实验被设计成确定这种行为反应的获得是否由脊髓的神经元介导（即，是中枢介导的）或反映外周修饰（例如，肌肉张力的变化）。第一个实验发现，切断坐骨神经阻止信息到达脊髓，会阻断这种行为反应的获得。脊髓损伤大鼠也未能学习，如果脊髓麻醉利多卡因在暴露于反应相关休克（实验2）。实验3表明，事先暴露于响应-应急休克的一条后腿促进收购的反应时，受试者后来测试对另一条腿。这些发现表明，获得的工具性反应取决于脊髓内的神经元。(C)2002年爱思唯尔科技有限公司All rights reserved.
Rats spinally transected at the second thoracic vertebra can learn to maintain their leg in a flexed position if they receive legshock for extending the limb. These rats display an increase in the duration of a flexion response that minimizes net shock exposure. The current set of experiments was designed to determine whether the acquisition of this behavioral response is mediated by the neurons of the spinal cord (i.e., is centrally mediated) or reflects a peripheral modification (e.g., a change in muscle tension). Experiment I found that preventing information from reaching the spinal cord by severing the sciatic nerve blocked the acquisition of this behavioral response. Spinalized rats also failed to learn if the spinal cord was anesthetized with lidocame during exposure to response-contingent shock (Experiment 2). Experiment 3 demonstrated that prior exposure to response-contingent shock on one hindleg facilitated acquisition of the response when subjects were later tested on the opposite leg. These findings suggest that acquisition of the instrumental response depends on neurons within the spinal cord. (C) 2002 Elsevier Science Inc. All rights reserved.