Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer
Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer
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ARNT2 过度表达与胃癌细胞增殖减少和更好的预后相关
DOI：
10.1007/s11010-018-3376-y
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发表时间：
2019-01-01
影响因子：
4.3
通讯作者：
Wang, Yunshan
中科院分区：
文献类型：
--
作者：
Jia, Yanfei;Hao, Shuhua;Wang, Yunshan
芳烃受体核转运蛋白（ARNT 2）是bHLH PAS（basic helix-loop-helix Period/ARNT/Single-minded）转录因子家族的成员。近年来研究表明ARNT 2与肿瘤的发生、发展有关。然而，其在胃癌（GC）中的作用仍不清楚。本研究发现ARNT 2在胃癌组织中的表达水平低于癌旁组织，且与胃癌的浸润深度、分化程度、患者的生存率呈负相关。ARNT 2的过表达抑制细胞增殖。此外，AKT通路有助于ARNT 2介导的PC增殖。总之，我们的研究结果提供了第一个证据，ARNT 2的高表达抑制GC细胞的增殖，并影响GC患者的肿瘤侵袭性。
Aryl hydrocarbon-receptor nuclear translocator (ARNT2) is a member of the bHLH PAS (basic helix-loop-helix Period/ARNT/Single-minded) family of transcription factors. Recently, some studies indicate that ARNT2 is associated with the occurrence and development of carcinoma. However, its roles in gastric cancer (GC) remain unclear. In the present study, we found that ARNT2 expression level is lower in GC tissues compared with adjacent non-tumor tissues, and negatively correlated with depth of invasion of the tumor, differentiated degree, and poor survival of GC patients. Overexpression of ARNT2 inhibits cell proliferation. Furthermore, AKT pathway contributed to ARNT2 -mediated PC proliferation. Taken together, our results provide the first evidence that high expression of ARNT2 inhibited proliferation of GC cells and affected tumor aggressiveness in GC patients.