Comparison of subjective grading and objective assessment in meibography
Comparison of subjective grading and objective assessment in meibography
复制标题
Meibography 主观分级与客观评估的比较
DOI：
10.1016/j.clae.2012.10.074
复制
发表时间：
2013-02-01
影响因子：
3.2
通讯作者：
Riede-Pult, Britta
中科院分区：
文献类型：
--
作者：
Pult, Heiko;Riede-Pult, Britta
目的：分析主观分级和客观评估的可重复性在非接触式红外meibografic.Methods：meibografic 24名受试者（女性14;平均年龄= 46;范围= 19-69岁，上眼睑图像= 12，下眼睑图像= 12）进行了分类，在两个会议上由三个经验丰富的观察员（OI，OII，OIII）。受睑板腺（MG）损失影响的相对面积或部分采用三种不同的分级量表按随机顺序进行分类：四级量表（4S）（0度=无部分腺体; 1 = 75%部分腺体），图形五级量表（5S）（0度=无睑板腺损失（MGL）; 1度= 75%MGL），并且客观地通过应用ImageJ软件的100级量表（DA）。5S观察员内部协议（OI：kappa = 0.80，p < 0.001; OII：kappa = 0.40，p = 0.009; OIII kappa = 0.81，p < 0.001）优于4S（OI：kappa = 0.79，p < 0.001; OII：kappa = 0.15，p = 0.342; OIII kappa = 0.50，p =0.0071）。在4S和5S中，OI和OIII的观察者内一致性（+/- 0.88（95%置信区间），+/- 1.305）优于OII（+/- 2.21）（分别为+/- 0.99，+/- 2.00和+/- 0.91; OI、OII和OIII），而在DA中相对相似（18、17和17）。观察者间的一致性在DA中更好（II-OII：+/- 13，OI-OII：+/- 19，OII-OIII：+/- 26）比4S（OI-OII：+1.76; OI-OIIII：+/- 1.29和OII-OIII：+/- 1.31）或5S（OI-OII：+/- 1.49; OI-OIII：+/- 0.91和OII-OIII：+/- 1.20）。结论：观察者内和观察者间的一致性在计算机评分中较好，其次是主观五级量表和四级量表。(C)2012年英国接触透镜协会。由爱思唯尔有限公司出版。保留所有权利。
Aim: To analyse repeatability of subjective grading and objective assessment in non-contact infra-red meibography.Methods: Meibography photographs of 24 subjects (female 14; mean age = 46; range = 19-69 years, upperlid images = 12, lower-lid images = 12) were classified in two sessions by three experienced observers (OI, OII, OIII). Relative area or portion affected by meibomian glands (MG) loss was classified applying three different grading scales in randomized order: a four-grade scale (4S) (degree 0=no partial glands; 1 = 75% partial glands), a pictorial five-grade scale (5S) (degree 0 = no meibomian gland loss (MGL); 1 = 75% MGL) and objectively by a 100-grade scale (DA) applying ImageJ software.Results: Observed MG loss ranged from 0% to 69%. Intra-observer agreement of the 5S (OI: kappa = 0.80, p < 0.001; OII: kappa = 0.40, p = 0.009; OIII kappa = 0.81, p < 0.001) was better than of the 4S (OI: kappa = 0.79, p < 0.001; OII: kappa = 0.15, p = 0.342; OIII kappa = 0.50, p =0.0071). Intra-observer agreement of OI and OIII (+/- 0.88 (95% confidence interval), +/- 1.305) was better than of OII (+/- 2.21) in 4S and 5S (+/- 0.99, +/- 2.00 and +/- 0.91; OI, OII and OIII, respectively) while it was relatively similar in DA ( 18, 17 and 17). Inter-observer agreement was better in DA (II-OII: +/- 13, OI-OII: +/- 19, OII-OIII: +/- 26) than in 4S (OI-OII: +1.76; OI-OIIII: +/- 1.29 and OII-OIII: +/- 1.31) or 5S (OI-OII: +/- 1.49; OI-OIII: +/- 0.91 and OII-OIII: +/- 1.20).Conclusion: Intra-observer and inter-observer agreement was better in computerized grading followed by the subjective five-grade scale and four-grade scale. (C) 2012 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.